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Twin Models*

Published online by Cambridge University Press:  01 August 2014

L. Gedda ,
G. Brenci  and
M. T. Lun
L. Gedda*
Affiliation:
The Gregor Mendel Institute of Medical Genetics and Twin Research, Rome
G. Brenci
Affiliation:
The Gregor Mendel Institute of Medical Genetics and Twin Research, Rome
M. T. Lun
Affiliation:
The Gregor Mendel Institute of Medical Genetics and Twin Research, Rome
*
Istituto di Genetica Medica e Gemellologia Gregorio Mendel, Piazza Galeno, 5, 00161 Roma, Italy

Extract

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The theoretical relationship between the distribution of a given trait in a population of twin pairs and several genetic parameters has been examined. In particular, a series of mathematical models has been worked out, that, when applied to a twin population, nonselected for the occurrence of a given trait and nondiagnosed as to zygosity, leads to an estimate of:

1) The MZ: DZ ratio in the population;

2) The frequency of the genotype responsible for a given trait;

3) The probability of manifestation of the trait;

4) The value of epistatic factors.

A further mathematical model affords the estimate of linkage in the hypothesis of simultaneous recording of more than one trait.

Type
Session 9 - Methodology of Twin Studies
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 19 , Issue 1-2 , April 1970 , pp. 141
Copyright
Copyright © The International Society for Twin Studies 1970

Footnotes

*

The full paper is being prepared and will soon be published.

References

* The full paper is being prepared and will soon be published.