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Reverse immunogenetic and polyepitopic approaches for the induction of cell-mediated immunity against bovine viral pathogens

Published online by Cambridge University Press:  28 February 2007

Nagendra R. Hegde  and
S. Srikumaran
Nagendra R. Hegde
Affiliation:
Department of Molecular Microbiology and Immunology, L220, Oregon Health Sciences University, 3181SW Sam Jackson Park Road, Portland, OR 97201–3098, University of Nebraska-Lincoln, Lincoln, NE 68583–0905, USA
S. Srikumaran*
Affiliation:
Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583–0905, USA
*
*Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583–0905, USA. E-mail: ssrikumaran1@unl.edu
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Abstract

The control of several infectious diseases of animals by vaccination is perhaps the most outstanding accomplishment of veterinary medicine in the last century. Even the eradication of some pathogens is in sight, at least in some parts of the world. However, infectious diseases continue to cost millions of dollars to the livestock industry. One of the reasons for the failure to control certain pathogens is the limited emphasis placed on cell-mediated immunity (CMI) in the design of vaccines against these pathogens. Traditionally, vaccine-induced immunity has been studied in relation to antibody-mediated protection. More recent studies, however, have focused on understanding CMI and developing means of inducing CMI. This review focuses on recent advances made in the study of CMI in general and of cytotoxic T lymphocytes in particular. Parallels from studies in human and mouse immunology are drawn in order to point out implications to bovine immunology, specifically for immunity against bovine herpesvirus 1.

Type
Research Article
Information
Animal Health Research Reviews , Volume 1 , Issue 2 , December 2000 , pp. 103 - 118
Copyright
Copyright © CAB International 2000

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