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Plant-made vaccines: biotechnology and immunology in animal health

Published online by Cambridge University Press:  08 March 2007

J. Rice ,
W. M. Ainley  and
P. Shewen
J. Rice*
Affiliation:
Dow AgroSciences, 9330 Zionsville Road, Indianapolis, IN 46268, USA
W. M. Ainley
Affiliation:
Dow AgroSciences, 9330 Zionsville Road, Indianapolis, IN 46268, USA
P. Shewen
Affiliation:
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada, N1G 2W1
*
*Corresponding author: Email: jrice3@dow.com
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Abstract

The use of plants as production systems for vaccine antigens has been actively investigated over the last 15 years. The original research focused on the value of this expression system for oral delivery based on the hypothesis that plant-expressed antigens would be more stable within the digestive tract and would allow for the use of the oral route of administration to stimulate a mucosal immune response. However, while first conceived for utility via the oral route, plant-made antigens have also been studied as classical immunogens delivered via a needle to model animal systems. Antigens have been expressed in a number of whole plant and cell culture systems. Several alternative expression platforms have been developed to increase expression of antigens or to elicit preferred immunological responses. The biotechnological advances in plant expression and the immunological testing of these antigens will be reviewed in this paper focusing primarily on diseases of livestock and companion animals.

Keywords

plant-madevaccineimmunogenicityanimal health
Type
Research Article
Information
Animal Health Research Reviews , Volume 6 , Issue 2 , December 2005 , pp. 199 - 209
Copyright
Copyright © CAB International 2005

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