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Associations between serum transferrin polymorphism and disturbed segregation ratios in Welsh Mountain sheep

Published online by Cambridge University Press:  02 September 2010

A. G. H. Khattab ,
J. H. Watson  and
R. F. E. Axford
A. G. H. Khattab
Affiliation:
School of Agriculture, University College of North Wales, Bangor
J. H. Watson
Affiliation:
School of Agriculture, University College of North Wales, Bangor
R. F. E. Axford
Affiliation:
School of Agriculture, University College of North Wales, Bangor
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Extract

Six serum transferrins have been found amongst 1,030 sheep in a Welsh Mountain sheep flock, apparently produced by six genes segregating as alleles at a single locus. All 21 possible phenotypes have been found.

The genes are designated TfA, TfB, Tfc, TfD, TfE and Tfp, TfA producing the fastest, and Tfp, the slowest migrating component. TfE and Tfp are at a much lower frequency (0·01 to 0·06) than the remaining genes (0·2 to 0·3) and Tfp may represent a fifteenth allele at this locus.

A comparison of observed phenotype frequencies with those expected under random mating, showed that a marked disturbance in segregation existed, with homozygous TfCC animals in consistent excess and a marked shortage of heterozygous TfBC and TfCD animals. Variation amongst remaining phenotypes appeared to be at random. However, incompatibility with the Tfc gene also extended to matings including Tfp. Examination of 282 matings confirmed that the effect of the Tfc gene favours maternal-foetal incompatibility as a cause of disturbed segregation, rather than selective fertilisation. However, reciprocal mating data were not available.

Type
Research Article
Information
Animal Production , Volume 6 , Issue 2 , June 1964 , pp. 207 - 213
Copyright
Copyright © British Society of Animal Science 1964

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References

REFERENCES

Ashton, G. C., 1958. Further β-globulin phenotypes in sheep. Nature (Lond.), 182: 1101.Google Scholar
Ashton, G. C., 1959. β-globulin polymorphism and early foetal mortality in cattle. Nature (Lond.), 183: 404.Google Scholar
Ashton, G. C., 1961. β-globulin type and fertility in artificially bred dairy cattle. J. Reprod. Fertil., 2: 117.Google Scholar
Ashton, G. C. & McDougall, E. I., 1958. β-globulin polymorphism in cattle, sheep and goats. Nature (Lond.), 182: 945.Google Scholar
Ashton, G. C. & Fallon, G. R., 1962. β-globulin type, fertility and embryonic mortality in cattle. J. Reprod. Fertil., 3: 93.Google Scholar
Ashton, G. C. & Ferguson, K. A., 1963. Serum transferrins in Merino sheep. Genet. Res. (Comb.), 4: 240.Google Scholar
Bateman, N., 1960. Selective fertilization at the T-locus of the mouse. Genet. Res. (Camb.), 1: 226.Google Scholar
Dalton, D. C., 1962. Characters of economic importance in Welsh Mountain sheep. Anim. Prod., 4: 269.Google Scholar
Gahne, B., 1961. Studies of transferrins in serum and milk of Swedish cattle. Anim. Prod., 3: 135.Google Scholar
Moustgaard, J., Moller, I. & Havskov Sørensen, P., 1960. βlaktoglobulintyper hos kvaeg. (β-lactoglobulin types in cattle.) Aarsberetn. Inst. Sterilitetsforskn. K. Vet.-og Landbohejsk. (Kbh.), 1960: 111Google Scholar
Ogden, A. L., 1960. β-globulin type and conception rate in artificially bred dairy cattle. Rep. 1th European Meeting on Blood Groups in Farm Animals, Edinburgh, p. 150.Google Scholar
Smithies, O., 1957. Variations in human serum β-globulin. Nature (Lond.), 180: 1482.Google Scholar
Smithies, O., 1959. Zone electrophoresis in starch gels and its application to studies of serum proteins. Advanc. Protein Chem., 14: 65.Google Scholar
Turnbull, A. & Giblett, E., 1960. The binding and transport of iron by unusual trans-ferrins. Clin. Res. Proc., 8: 133.Google Scholar