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Relationships between haemoglobin type and copper concentrations in whole blood and its components in sheep of different breeds

Published online by Cambridge University Press:  02 September 2010

Gerald Wiener ,
J. G. Hall ,
Susan Hayter ,
A. C. Field  and
N. F. Suttle
Gerald Wiener
Affiliation:
ARC Animal Breeding Research Organisation, West Mains Road, Edinburgh EH9 3JQ
J. G. Hall
Affiliation:
ARC Animal Breeding Research Organisation, West Mains Road, Edinburgh EH9 3JQ
Susan Hayter
Affiliation:
ARC Animal Breeding Research Organisation, West Mains Road, Edinburgh EH9 3JQ
A. C. Field
Affiliation:
Moredun Research Institute, Gilmerton Road, Edinburgh EH 17 7JH
N. F. Suttle
Affiliation:
Moredun Research Institute, Gilmerton Road, Edinburgh EH 17 7JH
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Summary

Copper concentrations were determined in whole blood, plasma and caeruloplasmin and calculated for red cells and non-caeruloplasmin copper in plasma in 215 female sheep, 9 months old, belonging to the Scottish Blackface, Cheviot and Welsh Mountain breeds of sheep and their crosses. Copper determinations were also made on red cells and plasma, and calculated for whole blood, of a contemporary group of 107 female sheep of the same breeds at the age of 4 years. Further, plasma copper concentrations were determined for these 107 sheep from samples taken on several occasions some years earlier.

Within breed, sheep of type Hb B had significantly higher levels of copper than sheep of type Hb A in whole blood and most of the blood components. The biggest differences were found in plasma and were 19 ng/100 ml for one group and 37 Jig/100 ml for the other. Type Hb AB sheep were intermediate in copper level. The differences in plasma copper level associated with Hb type were present and of similar magnitude at different ages, seasons and average flock levels of copper.

After adjustment for the effects of Hb type, breed differences in copper levels were significant for whole blood and all components but much less pronounced for red cells than for plasma. Copper levels in plasma and red cells were only moderately correlated (r = 0·23–0·40).

Combined evidence suggests the existence of a gene with a marked effect on copper level which is linked to the locus for Hb type.

Type
Research Article
Information
Animal Production , Volume 19 , Issue 3 , December 1974 , pp. 291 - 299
Copyright
Copyright © British Society of Animal Science 1974

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References

REFERENCES

Hayter, Susan, Wiener, Gerald and Field, A. C. 1973. Variation in the concentration of copper in the blood plasma of Finnish Landrace and Merino sheep and their crosses with particular reference to reproductive performance and age. Anim. Prod. 16: 261–269.Google Scholar
Smith, B. S. W. and Wright, H. 1974. Improved manual and automated procedures for estimation of caeruloplasmin oxidase activity. Clinica chim. Ada 50: 359–366.CrossRefGoogle Scholar
Suttle, N. F. 1974. A technique for measuring the biological availability of copper to sheep using hypocupraemic ewes. Br. J. Nutr. 32: 395–405.Google Scholar
Suttle, N. F. and Field, A. C. 1968. Effect of intake of copper, molybdenum and sulphate on copper metabolism in sheep. I. Clinical condition and blood copper distribution in the pregnant ewe. J. comp. Path. 78: 351–363.CrossRefGoogle ScholarPubMed
Thompson, R. H. and Blanchflower, W. J. 1971. Wet-ashing apparatus to prepare biological materials for atomic absorption spectrophotometry. Lab. Pract. 20: 859–861.Google ScholarPubMed
Wiener, Gerald and Field, A. C. 1966. Blood copper-levels in sheep in relation to genetic factors, parity and previous swayback history. Nature, Lond. 209: 835–836.CrossRefGoogle ScholarPubMed
Wiener, Gerald and Field, A. C. 1971. The concentration of minerals in the blood of genetically diverse groups of sheep. V. Concentrations of copper, calcium, phosphorus, magnesium, potassium and sodium in the blood of lambs and ewes. J. agric. Sci., Camb. 76: 513–520.Google Scholar
Wiener, Gerald and Field, A. C. 1974. Seasonal changes, breed differences and repeatability of plasma copper levels of sheep at pasture. J. agric. Sci., Camb. (in press).Google Scholar
Wiener, Gerald, Field, A. C. and Wood, Jean, 1969. The concentration of minerals in the blood of genetically diverse groups of sheep. I. Copper concentrations at different seasons in Blackface, Cheviot, Welsh Mountain and crossbred sheep at pasture. J. agric. Sci., Camb. 72: 93–101.CrossRefGoogle Scholar
Wiener, Gerald, Hall, J. G. and Hayter, Susan. 1973. An association between the concentration of copper in whole blood and haemoglobin type in sheep. Anim. Prod. 17: 1–7.Google Scholar
Wiener, Gerald, Hall, J. G. and Hayter, Susan. 1974. An association between copper concentration in blood and hemoglobin type in sheep. In Trace Element Metabolism in Animals—2 (ed. Hoekstra, W. G., Suttie, J. W., Ganther, H. E. and Mertz, W.). University Park Press, Baltimore, Md. pp. 605–607.Google Scholar