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Interactions of the bovine placental lactogen and prolactin receptor genes are associated with fertility traits in cattle

Published online by Cambridge University Press:  16 September 2009

W. Huang ,
D. Mikhail ,
A. C. Bindrim  and
H. Khatib
W. Huang
Affiliation:
Department of Dairy Science, University of Wisconsin, Madison, WI 53706, USA
D. Mikhail
Affiliation:
Department of Dairy Science, University of Wisconsin, Madison, WI 53706, USA
A. C. Bindrim
Affiliation:
Department of Dairy Science, University of Wisconsin, Madison, WI 53706, USA
H. Khatib*
Affiliation:
Department of Dairy Science, University of Wisconsin, Madison, WI 53706, USA
*
†E-mail: hkhatib@wisc.edu
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Abstract

Decline in fertility of high-producing dairy cattle has become a global challenge to the dairy industry. Because of low heritability and complexity, it is difficult to find genetic markers for fertility traits in cattle. Here, we report the use of an in vitro fertilization (IVF) system and candidate gene approach to test genetic associations of a single-nucleotide polymorphism (SNP) in bovine placental lactogen (bPL), and its interactions with SNPs in the prolactin receptor (PRLR) and growth hormone receptor genes with fertility traits in an IVF system. The associations suggest a possible involvement of genetic interactions between bPL and PRLR in the fertilization and embryonic development processes, and the potential for application in a marker-assisted selection program.

Keywords

bovine placental lactogencandidate genefertilityepistasis
Type
Full Paper
Information
animal , Volume 3 , Issue 12 , December 2009 , pp. 1743 - 1745
Copyright
Copyright © The Animal Consortium 2009

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