Hostname: page-component-84b7d79bbc-x5cpj Total loading time: 0 Render date: 2024-07-25T22:18:41.088Z Has data issue: false hasContentIssue false
  • English
  • Français

Alpha-lipoic acid

Published online by Cambridge University Press:  11 September 2013

Get access

In a nutshell

ALA is a powerful antioxidant, both water and lipid soluble, that can also regenerate other antioxidants.

A range of ‘antioxidant’ and other clinical indications (such as chelating toxic metals) have been tested in small, open trials and/or animal studies. The most convincing clinical evidence so far is for a possible role in diabetes, particularly in treating diabetic neuropathy.

Type
Brief Report
Information
Arbor Clinical Nutrition Updates , Volume 238 , January 2006 , pp. 1 - 2
Copyright
Copyright © Cambridge University Press 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Kidd, PM. Neurodegeneration from mitochondrial insufficiency: nutrients, stem cells, growth factors, and prospects for brain rebuilding using integrative management. Altern Med Rev. 2005 Dec;10(4):268–93.Google Scholar
2. Wollin, SD. et al. Alpha-lipoic acid and cardiovascular disease. J Nutr. 2003 Nov;133(11):3327–30.Google Scholar
3. Anon alpha-Lipoic acid. Altern Med Rev. 1998 Aug;3(4):308–10.Google Scholar
4. Evans, JL. et al. Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technol Ther. 2000 Autumn;2(3):401–13.Google Scholar
5. Jacob, S. et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radic Biol Med. 1999 Aug;27(3–4):309–14.Google Scholar
6. Henriksen, EJ. Exercise training and the antioxidant alpha-lipoic acid in the treatment of insulin resistance and type 2 diabetes. Free Radic Biol Med. 2006 Jan 1;40(1):3–12.Google Scholar
7. Malik, RA. Current and future strategies for the management of diabetic neuropathy. Treat Endocrinol. 2003;2(6):389–400.Google Scholar
8. Cowell, RM. et al. Nitrosative injury and antioxidant therapy in the management of diabetic neuropathy. J Investig Med. 2004 Jan;52(1):33–44.Google Scholar
9. Ziegler, D. et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis. Diabet Med. 2004 Feb;21(2):114–21.Google Scholar
10. Tankova, T. et al. Treatment for diabetic mononeuropathy with alpha-lipoic acid. Int J Clin Pract. 2005 Jun;59(6):645–50.Google Scholar
11. Melhem, MF. et al. Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus. J Am Soc Nephrol. 2001 Jan;12(1):124–33.Google Scholar
12. Tylicki, L. et al. Antioxidants: a possible role in kidney protection. Kidney Blood Press Res. 2003;26(5–6):303–14.Google Scholar
13. Smith, AR. et al. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem. 2004 May;11(9):1135–46.Google Scholar
14. Patrick, L. Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity. Altern Med Rev. 2002 Dec;7(6):456–71.Google Scholar
15. Savitha, S. et al. Efficacy of levo carnitine and alpha lipoic acid in ameliorating the decline in mitochondrial enzymes during aging. Clin Nutr. 2005 Oct;24(5):794–800.Google Scholar
16. Sauer, J. et al. Alpha lipoic acid for dementia. Cochrane Database Syst Rev. 2004;(1):CD004244.Google Scholar
17. Morcos, M. et al. Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study. Diabetes Res Clin Pract. 2001 Jun;52(3):175–83.Google Scholar
18. Zakrzewska, JM. et al. Interventions for the treatment of burning mouth syndrome. Cochrane Database Syst Rev. 2005 Jan 25;(1):CD002779.Google Scholar
19. Doggrell, SA. Alpha-lipoic acid, an anti-obesity agent? Expert Opin Investig Drugs. 2004 Dec;13(12):1641–3.Google Scholar
20. Mantovani, G. et al. Cancer-related anorexia/cachexia syndrome and oxidative stress: an innovative approach beyond current treatment. Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1651–9.Google Scholar
21. de Champlain, J. et al. Oxidative stress in hypertension. Clin Exp Hypertens. 2004 Oct-Nov;26(7–8):593–601.Google Scholar
22. Beitner, H. Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin. Br J Dermatol. 2003 Oct;149(4):841–9.Google Scholar
23. Bustamante, J. et al. Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med. 1998 Apr;24(6):1023–39.CrossRefGoogle ScholarPubMed
24. Teichert, J. et al. Pharmacokinetics of alpha-lipoic acid in subjects with severe kidney damage and end-stage renal disease. J Clin Pharmacol. 2005 Mar;45(3):313–28.Google Scholar
25. Ziegler, D. Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review. Treat Endocrinol. 2004;3(3):173–89.Google Scholar