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Chronic fatigue syndrome

Published online by Cambridge University Press:  11 September 2013

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In a nutshell

Various nutrition links have been proposed for CFS. The most likely to have some validity are an imbalance of LCPFA, or of amino acids and the neurotransmitters synthesised from them. There may be some antioxidant stress involved as well.

Unfortunately, the body of clinical trial evidence does not add up to any firm conclusion, despite the popularity of nutritional treatments amongst CFS patients.

Type
Brief Report
Copyright
Copyright © Cambridge University Press 2007

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References

1. Chambers, D. et al. Interventions for the treatment, management and rehabilitation of patients with chronic fatigue syndrome/myalgic encephalomyelitis: an updated systematic review. J R Soc Med. 2006 Oct;99(10):506–20.Google Scholar
2. Reeves, WC. et al. Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution. BMC Health Serv Res. 2003 Dec 31;3(1):25.Google Scholar
3. Hamilton, WT. et al. The prognosis of different fatigue diagnostic labels: a longitudinal survey. Fam Pract. 2005 Aug;22(4):383–8.Google Scholar
4. Fukuda, K. et al. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med. 1994 Dec 15;121(12):953–9.CrossRefGoogle ScholarPubMed
5. Craig, T. et al. Chronic fatigue syndrome: evaluation and treatment. Am Fam Physician. 2002 Mar 15;65(6):1083–90.Google Scholar
6. Armstrong, DJ. et al. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol. 2007 Apr;26(4):551554.CrossRefGoogle ScholarPubMed
7. Moorkens, G. et al. Magnesium deficit in a sample of the Belgian population presenting with chronic fatigue. Magnes Res. 1997 Dec;10(4):329–37.Google Scholar
8. Marcusson, JA. The frequency of mercury intolerance in patients with chronic fatigue syndrome and healthy controls. Contact Dermatitis. 1999 Jul;41(1):60–1.Google Scholar
9. Borish, L. et al. Chronic fatigue syndrome: identification of distinct subgroups on the basis of allergy and psychologic variables. J Allergy Clin Immunol. 1998 Aug;102(2):222–30.Google Scholar
10. Werbach, MR. Nutritional strategies for treating chronic fatigue syndrome. Altern Med Rev. 2000 Apr;5(2):93108.Google Scholar
11. Logan, AC. et al. Chronic fatigue syndrome: oxidative stress and dietary modifications. Altern Med Rev. 2001 Oct;6(5):450–9.Google Scholar
12. Richards, RS. et al. Blood parameters indicative of oxidative stress are associated with symptom expression in chronic fatigue syndrome. Redox Rep. 2000;5(1):3541.Google Scholar
13. Lindh, U. et al. Removal of dental amalgam and other metal alloys supported by antioxidant therapy alleviates symptoms and improves quality of life in patients with amalgam-associated ill health. Neuro Endocrinol Lett. 2002 Oct-Dec;23(5–6):459–82.Google ScholarPubMed
14. Kuratsune, H. et al. Acylcarnitine deficiency in chronic fatigue syndrome. Clin Infect Dis. 1994 Jan;18 Suppl 1:S62–7.Google Scholar
15. Plioplys, AV. et al. Serum levels of carnitine in chronic fatigue syndrome: clinical correlates. Neuropsychobiology. 1995;32(3):132–8.Google Scholar
16. Soetekouw, PM. et al. Normal carnitine levels in patients with chronic fatigue syndrome. Neth J Med. 2000 Jul;57(1):20–4.Google Scholar
17. Heap, LC. et al. Vitamin B status in patients with chronic fatigue syndrome. J R Soc Med. 1999 Apr;92(4):183–5.Google Scholar
18. Kaslow, JE. et al. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med. 1989 Nov;149(11):2501–3.Google Scholar
19. Forsyth, LM. et al. Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome. Ann Allergy Asthma Immunol. 1999 Feb;82(2):185–91.Google Scholar
20. Mutter, J. et al. Elimination of xenobiotics in a female patient with fibromyalgia, chronic fatigue, and trunk obesity. Forsch Komplementarmed. 2007 Feb;14(1):3944.Google Scholar
21. Emms, TM. et al. Food intolerance in chronic fatigue syndrome. Abstract #15 presented at the American Association for Chronic Fatigue Syndrome conference. January 2001. Seattle, WA. See ref.#11Google Scholar
22. Borok, G. Another answer to yuppie flu? S Afr Med J. 1989;76(4):176.Google Scholar
23. Gibson, SL. et al. A multidimensional treatment plan for chronic fatigue syndrome. J Nutr Environ Med 1999;9:4754. See ref.#11.CrossRefGoogle Scholar
24. Logan, AC. et al. Chronic fatigue syndrome: lactic acid bacteria may be of therapeutic value. Med Hypotheses. 2003 Jun;60(6):915–23.Google Scholar
25. Castell, LM. et al. The role of tryptophan in fatigue in different conditions of stress. Adv Exp Med Biol. 1999;467:697704.CrossRefGoogle ScholarPubMed
26. Helman, A. Leucine and sport. Arb Clin Nutr Upd. 2007;277:13.Google Scholar
27. Georgiades, E. et al. Chronic fatigue syndrome: new evidence for a central fatigue disorder. Clin Sci (Lond). 2003 Aug;105(2):213–8.Google Scholar
28. Puri, BK. Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). J Clin Pathol. 2007 Feb;60(2):122–4.Google Scholar
29. Nicolson, GL. et al. Lipid replacement and antioxidant nutritional therapy for restoring mitochondrial function and reducing fatigue in chronic fatigue syndrome and other fatiguing illnesses. J Chronic Fatigue Synd. 2006; 13(1): 5768.Google Scholar
30. Puri, BK. The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome. Prostaglandins Leukot Essent Fatty Acids. 2004 Apr;70(4):399401.Google Scholar
31. Puri, BK. et al. Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes. Int J Clin Pract. 2004 Mar;58(3):297–9.Google Scholar
32. Behan, PO. et al. Effect of high doses of essential fatty acids on the postviral fatigue syndrome. Acta Neurol Scand. 1990 Sep;82(3):209–16.Google Scholar
33. Warren, G. et al. The role of essential fatty acids in chronic fatigue syndrome. A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA. Acta Neurol Scand. 1999 Feb;99(2):112–6.Google Scholar
34. Cox, IM. et al. Red blood cell magnesium and chronic fatigue syndrome. Lancet. 1991 Mar 30;337(8744):757–60.Google Scholar
35. Plioplys, AV. et al. Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. Neuropsychobiology. 1997;35(1):1623.Google Scholar
36. Azad, KA. et al. Vegetarian diet in the treatment of fibromyalgia. Bangladesh Med Res Counc Bull. 2000 Aug;26(2):41–7.Google Scholar
37. Michalsen, A. et al. [Short-term therapeutic fasting in the treatment of chronic pain and fatigue syndromes--well-being and side effects with and without mineral supplements] Forsch Komplementarmed Klass Naturheilkd. 2002 Aug;9(4):221–7.Google Scholar
38. Brouwers, FM. et al. The effect of a polynutrient supplement on fatigue and physical activity of patients with chronic fatigue syndrome: a double-blind randomized controlled trial. QJM. 2002 Oct;95(10):677–83.CrossRefGoogle ScholarPubMed
39. LeGal, M. et al. Pharmaton Capsules in the treatment of functional fatigue: A double-blind study versus placebo evaluated by a new methodology. Phytotherapy Research 1996 10 (1): 4953.Google Scholar
40. Bentler, SE. et al. Prospective observational study of treatments for unexplained chronic fatigue. J Clin Psychiatry. 2005 May;66(5):625–32.Google Scholar
41. Rimes, KA. et al. Treatments for chronic fatigue syndrome. Occup Med (Lond). 2005 Jan;55(1):32–9.Google Scholar
42. Whiting, P. et al. Interventions for the treatment and management of chronic fatigue syndrome: a systematic review. JAMA. 2001 Sep 19;286(11):1360–8.Google Scholar