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Coeliac disease: part 1

Published online by Cambridge University Press:  11 September 2013

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In a nutshell

Malabsorption in CD can result in deficiencies of various nutrients, including folate, B12, B6, iron, magnesium and calcium, the latter leading to higher risk of osteoporosis and fractures.

Gluten avoidance will improve all of these, but it may take quite some time - up to several years in some cases. Appropriate nutritional testing and supplements should be considered.

Type
Brief Report
Copyright
Copyright © Cambridge University Press 2009

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References

1. Sanz, Y. et al. Differences in faecal bacterial communities in coeliac and healthy children as detected by PCR and denaturing gradient gel electrophoresis. FEMS Immunol Med Microbiol. 2007 Dec;51(3):562–8.Google Scholar
2. Barton, SH. et al. Nutritional deficiencies in celiac disease. Gastroenterol Clin North Am. 2007 Mar;36(1):93108, vi.Google Scholar
3. Dickey, W. Joint BAPEN and British Society of Gastroenterology Symposium on ‘Coeliac disease: basics and controversies’. Coeliac disease in the twenty-first century. Proc Nutr Soc. 2009 Aug;68(3):234–41.Google Scholar
4. Harper, JW. et al. Anemia in celiac disease is multifactorial in etiology. Am J Hematol. 2007 Nov;82(11):9961000.Google Scholar
5. Dickey, W. Low serum vitamin B12 is common in coeliac disease and is not due to autoimmune gastritis. Eur J Gastroenterol Hepatol. 2002 Apr;14(4):425–7.Google Scholar
6. Dahele, A. et al. Vitamin B12 deficiency in untreated celiac disease. Am J Gastroenterol. 2001 Mar;96(3):745–50.CrossRefGoogle ScholarPubMed
7. Dickey, W. et al. Homocysteine and related B-vitamin status in coeliac disease: Effects of gluten exclusion and histological recovery. Scand J Gastroenterol. 2008;43(6):682–8.Google Scholar
8. Saibeni, S. et al. Prevalence of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of B12, folate, and genetics. Clin Gastroenterol Hepatol. 2005 Jun;3(6):574–80.CrossRefGoogle ScholarPubMed
9. Pittschieler, K. [Folic acid concentration in the serum and erythrocytes of patients with celiac disease] Padiatr Padol. 1986;21(4):363–6.Google ScholarPubMed
10. Kitis, G. et al. Altered jejunal surface pH in coeliac disease: its effect on propranolol and folic acid absorption. Clin Sci (Lond). 1982 Oct;63(4):373–80.Google Scholar
11. Hallert, C. et al. Serum folate determinations in tracing adult coeliacs. Scand J Gastroenterol. 1981;16(2):263–7.Google Scholar
12. Weir, DG. et al. Coeliac disease during the teenage period: the value of serial serum folate estimations. Gut. 1974 Jun;15(6):450–7.CrossRefGoogle ScholarPubMed
13. Howard, MR. et al. A prospective study of the prevalence of undiagnosed coeliac disease in laboratory defined iron and folate deficiency. J Clin Pathol. 2002 Oct;55(10):754–7.CrossRefGoogle ScholarPubMed
14. Clayton, PT. B6-responsive disorders: a model of vitamin dependency. J Inherit Metab Dis. 2006 Apr-Jun;29(2–3):317–26.Google Scholar
15. Reinken, L. et al. Vitamin B-6 absorption in children with acute celiac disease and in control subjects. J Nutr. 1978 Oct;108(10):1562–5.CrossRefGoogle ScholarPubMed
16. Hallert, C. et al. High level of pyridoxal 5'-phosphate in the cerebrospinal fluid of adult celiac patients. Am J Clin Nutr. 1982 Nov;36(5):851–4.CrossRefGoogle ScholarPubMed
17. Cooke, WT. The neurological manifestations of malabsorption. Postgrad Med J. 1978 Nov;54(637):760–2.Google Scholar
18. Morris, JS. et al. Neurological disorders and adult coeliac disease. Gut. 1970 Jul;11(7):549–54.Google Scholar
19. Kowlessar, OD. et al. Abnormal tryptophan metabolism in patients with adult celiac disease, with evidence for deficiency of vitamin B6. J Clin Invest. 1964 May;43:894903.Google Scholar
20. Hallert, C. et al. Reversal of psychopathology in adult coeliac disease with the aid of pyridoxine (vitamin B6). Scand J Gastroenterol. 1983 Mar;18(2):299304.Google Scholar
21. Halfdanarson, TR. et al. Hematologic manifestations of celiac disease. Blood. 2007 Jan 15;109(2):412–21.Google Scholar
22. Bottaro, G. et al. The clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive cases. Am J Gastroenterol. 1999 Mar;94(3):691–6.Google ScholarPubMed
23. Fisgin, T. et al. Hematologic manifestation of childhood celiac disease. Acta Haematol. 2004;111(4):211–4.Google Scholar
24. Kapur, G. et al. Iron supplementation in children with celiac disease. Indian J Pediatr. 2003 Dec;70(12):955–8.Google Scholar
25. Carroccio, A. et al. Sideropenic anemia and celiac disease: one study, two points of view. Dig Dis Sci. 1998 Mar;43(3):673–8.Google Scholar
26. Logan, RF. et al. How often is a positive faecal occult blood test the result of coeliac disease? Eur J Gastroenterol Hepatol. 2003 Oct;15(10):1097–100.Google Scholar
27. Shamir, R. et al. Faecal occult blood in children with coeliac disease. Eur J Pediatr. 2000 Nov;159(11):832–4.Google Scholar
28. Fine, KD. The prevalence of occult gastrointestinal bleeding in celiac sprue. N Engl J Med. 1996 May 2;334(18):1163–7.Google Scholar
29. Annibale, B. et al. Efficacy of gluten-free diet alone on recovery from iron deficiency anemia in adult celiac patients. Am J Gastroenterol. 2001 Jan;96(1):132–7.Google Scholar
30. Halfdanarson, TR. et al. Copper deficiency in celiac disease. J Clin Gastroenterol. 2009 Feb;43(2):162–4.Google Scholar
31. Ince, AT. et al. Serum copper, ceruloplasmin and 24-h urine copper evaluations in celiac patients. Dig Dis Sci. 2008 Jun;53(6):1564–72.Google Scholar
32. Jameson, S. et al. Copper malabsorption in coeliac disease. Sci Total Environ. 1985 Mar 15;42(1–2):2936.Google Scholar
33. Singhal, N. et al. Serum zinc levels in celiac disease. Indian Pediatr. 2008 Apr;45(4):319–21.Google Scholar
34. Altuntas, . et al. Can zinc deficiency be used as a marker for the diagnosis of celiac disease in Turkish children with short stature? Pediatr Int. 2000 Dec;42(6):682–4.Google Scholar
35. Crofton, RW. et al. Zinc metabolism in celiac disease. Am J Clin Nutr. 1990 Aug;52(2):379–82.Google Scholar
36. Henker, J. et al. [Serum zinc levels in children with celiac disease] Helv Paediatr Acta. 1985 Apr;40(1):4753.Google Scholar
37. Jones, PE. et al. Oral zinc supplements in non-responsive coeliac syndrome: effect on jejunal morphology, enterocyte production, and brush border disaccharidase activities. Gut. 1981 Mar;22(3):194–8.Google Scholar
38. Uspenskaia, ID. [The efficacy of the use of lactic acid lactobacterin enriched with zinc in the treatment of patients with celiac disease] Vopr Pitan. 1991 Jul-Aug;(4):24–7.Google Scholar
39. Kelleher, J. et al. Essential element nutritional status in cystic fibrosis. Hum Nutr Appl Nutr. 1986 Apr;40(2):7984.Google Scholar
40. Ogilvie, D. et al. Urinary outputs of oxalate, calcium, and magnesium in children with intestinal disorders. Potential cause of renal calculi. Arch Dis Child. 1976 Oct;51(10):790–5.Google Scholar
41. Goldman, AS. et al. Magnesium deficiency in celiac disease. Pediatrics. 1962 Jun;29:948–52.Google Scholar
42. Rude, RK. et al. Magnesium deficiency: possible role in osteoporosis associated with gluten-sensitive enteropathy. Osteoporos Int. 1996;6(6):453–61.Google Scholar
43. Zanchi, C. et al. Bone metabolism in celiac disease. J Pediatr. 2008 Aug;153(2):262–5.CrossRefGoogle ScholarPubMed
44. Moreno, ML. et al. Stratification of bone fracture risk in patients with celiac disease. Clin Gastroenterol Hepatol. 2004 Feb;2(2):127–34.Google Scholar
45. Sdepanian, VL. et al. Bone mineral density of the lumbar spine in children and adolescents with celiac disease on a gluten-free diet in São Paulo, Brazil. J Pediatr Gastroenterol Nutr. 2003 Nov;37(5):571–6.Google Scholar
46. Vasquez, H. et al. Risk of fractures in celiac disease patients: a cross-sectional, case-control study. Am J Gastroenterol. 2000 Jan;95(1):183–9.Google Scholar
47. Sategna-Guidetti, C. et al. The effects of 1-year gluten withdrawal on bone mass, bone metabolism and nutritional status in newly-diagnosed adult coeliac disease patients. Aliment Pharmacol Ther. 2000 Jan;14(1):3543.Google Scholar
48. Mautalen, C. et al. Effect of treatment on bone mass, mineral metabolism, and body composition in untreated celiac disease patients. Am J Gastroenterol. 1997 Feb;92(2):313–8.Google Scholar
49. Scott, EM. et al. Guidelines for osteoporosis in coeliac disease and inflammatory bowel disease. British Society of Gastroenterology. Gut. 2000 Jan;46 Suppl 1:i18.Google ScholarPubMed
50. Corazza, GR. et al. Bone mass and metabolism in patients with celiac disease. Gastroenterology. 1995 Jul;109(1):122–8.Google Scholar
51. Pazianas, M. et al. Calcium absorption and bone mineral density in celiacs after long term treatment with gluten-free diet and adequate calcium intake. Osteoporos Int. 2005 Jan;16(1):5663.CrossRefGoogle ScholarPubMed
52. Capriles, VD. et al. Metabolic osteopathy in celiac disease: importance of a gluten-free diet. Nutr Rev. 2009 Oct;67(10):599606.Google Scholar
53. Kemppainen, T. et al. Bone recovery after a gluten-free diet: a 5-year follow-up study. Bone. 1999 Sep;25(3):355–60.Google Scholar