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Association between total dietary antioxidant capacity and food groups and incidence of depression in a cohort of Brazilian graduates (CUME Project)

Published online by Cambridge University Press:  01 February 2023

Gabriela Amorim Pereira Sol Open the ORCID record for Gabriela Amorim Pereira Sol [Opens in a new window] ,
Helen Hermana Miranda Hermsdorff Open the ORCID record for Helen Hermana Miranda Hermsdorff [Opens in a new window] ,
Arieta Carla Gualandi Leal ,
Adriano Marçal Pimenta ,
Josefina Bressan ,
Ana Paula Boroni Moreira  and
Aline Silva de Aguiar
Gabriela Amorim Pereira Sol*
Affiliation:
Faculty of Medicine, Department of Collective Health, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Helen Hermana Miranda Hermsdorff
Affiliation:
Laboratory of Energy Metabolism and Body Composition, Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil
Arieta Carla Gualandi Leal
Affiliation:
Laboratory of Energy Metabolism and Body Composition, Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil
Adriano Marçal Pimenta
Affiliation:
Department of Nursing, Universidade Federal do Paraná, Curitiba, Paraná, Brazil
Josefina Bressan
Affiliation:
Laboratory of Energy Metabolism and Body Composition, Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil
Ana Paula Boroni Moreira
Affiliation:
Department of Nutrition, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Aline Silva de Aguiar
Affiliation:
Faculty of Medicine, Department of Collective Health, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil Department of Nutrition and Dietetics, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil
*
*Corresponding author: Gabriela Amorim Pereira Sol, email gabiamorimpereira3@gmail.com
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Abstract

This study aims to evaluate the association between Dietary Total Antioxidant Capacity (dTAC) and Total Antioxidant Capacity of food groups (fgTAC) with the incidence of depression in Brazilian graduates participating in the Cohort of Universities of Minas Gerais (CUME Study). The sample consisted of 2572 participants without a medical diagnosis of depression at baseline who responded to at least one follow-up questionnaire from the CUME Project. The Ferric Reducing Antioxidant Power assay was used to determine dTAC. Incidence of depression was estimated by self-reported medical diagnosis of depression during the years of cohort follow-up. Cox regression models were used to relate dTAC and fgTAC to the incidence of depression. The mean follow-up time was 2·96 (1·00) years, and 246 cases of depression were observed (32·3/1000 person-years). The mean dTAC was 11·03 (4·84) mmol/d. We found no associations between higher dTAC and lower risk of developing depression after adjusting for possible confounders. The incidence of depression was inversely associated with fgTAC of the beans and lentils group (hazard ratio (HR): 0·61; 95 % CI 0·41, 0·90). The fgTAC of the junk food group was positively associated with higher incidence of depression after all adjustments (HR: 1·57; 95 % CI 1·08, 2·26). Our findings do not support an association between dTAC and the incidence of depression in a highly educated Brazilian population. However, associations of fgTAC show the importance of analysing the food matrix in which these antioxidants are inserted. We highlight the need for more prospective studies with different nationalities to confirm these results.

Keywords

Dietary Total Antioxidant CapacityDepressionEpidemiologyOxidative stress
Type
Research Article
Information
British Journal of Nutrition , Volume 130 , Issue 7 , 14 October 2023 , pp. 1155 - 1166
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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