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High-dose cholecalciferol supplementation to obese infertile men is sufficient to reach adequate vitamin D status

Published online by Cambridge University Press:  09 October 2023

Rune Holt Open the ORCID record for Rune Holt [Opens in a new window] ,
Mads Joon Jorsal ,
Sam Kafai Yahyavi ,
Simeng Qin ,
Anders Juul ,
Niels Jørgensen  and
Martin Blomberg Jensen
Rune Holt
Affiliation:
Group of Skeletal, Mineral and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark Department of Endocrinology and Internal Medicine, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark
Mads Joon Jorsal
Affiliation:
Group of Skeletal, Mineral and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark Department of Endocrinology and Internal Medicine, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark
Sam Kafai Yahyavi
Affiliation:
Group of Skeletal, Mineral and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark Department of Endocrinology and Internal Medicine, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark
Simeng Qin
Affiliation:
Group of Skeletal, Mineral and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark Department of Endocrinology and Internal Medicine, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark
Anders Juul
Affiliation:
Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Niels Jørgensen
Affiliation:
Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark
Martin Blomberg Jensen*
Affiliation:
Group of Skeletal, Mineral and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark Department of Endocrinology and Internal Medicine, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark
*
*Corresponding author: Martin Blomberg Jensen, emails :martin.blomberg.jensen@regionh.dk, blombergjensen@gmail.com
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Abstract

Obesity is associated with low vitamin D status, and the optimal supplement and dosage of cholecalciferol (vitamin D3) or calcidiol (25OHD) for individuals with obesity have been debated. We aimed to determine the effect of high-dose vitamin D3 supplementation on achieving adequate vitamin D levels among infertile men with normal weight v. obesity. Here, we present secondary end points from a single-centre, double-blinded, randomised clinical trial, comprising 307 infertile men randomised to active or placebo treatment for 150 days. Men in the active group initially received an oral bolus of 300 000 mg of vitamin D3, followed by daily supplementation with 1400 mg of vitamin D3 and 500 mg of calcium. Baseline BMI was listed as a predefined subgroup. At baseline, serum 25OHD was significantly higher in men with normal weight (BMI < 25 kg/m2) compared with men with overweight (BMI 25–30 kg/m2) and obesity (BMI > 30 kg/m2) (48 nmol/l v. 45 nmol/l and 39 nmol/l, respectively; P = 0·024). After the intervention, men with normal weight, overweight and obesity treated with vitamin D3 had a significantly higher serum 25OHD compared with corresponding placebo-treated men (BMI < 25 kg/m2: 92 nmol/l v. 53 nmol/l, BMI = 25–30 kg/m2: 87 nmol/l v. 49 nmol/l and BMI > 30 kg/m2: 85 nmol/l v. 48 nmol/l; P < 0·001 for all, respectively). In conclusion, we show that high-dose vitamin D3 supplementation to infertile men with obesity and low vitamin D status is sufficient to achieve adequate serum 25OHD levels.

Keywords

Vitamin DObesitySupplementsMale infertility
Type
Research Article
Information
British Journal of Nutrition , Volume 131 , Issue 4 , 28 February 2024 , pp. 642 - 647
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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