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Association of sarcopenia with rapid kidney function decline and chronic kidney disease in adults with normal kidney function

Published online by Cambridge University Press:  16 October 2023

Xiaowei Zheng Open the ORCID record for Xiaowei Zheng [Opens in a new window] ,
Xiao Ren ,
Minglan Jiang ,
Longyang Han  and
Chongke Zhong
Xiaowei Zheng*
Affiliation:
Public Health Research Center and Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, People’s Republic of China
Xiao Ren
Affiliation:
Public Health Research Center and Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, People’s Republic of China
Minglan Jiang
Affiliation:
Public Health Research Center and Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, People’s Republic of China
Longyang Han
Affiliation:
Public Health Research Center and Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, People’s Republic of China
Chongke Zhong*
Affiliation:
Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215000, People’s Republic of China
*
*Corresponding authors: Xiaowei Zheng, email zxw19921212@163.com; Chongke Zhong, email ckzhong@suda.edu.cn
*Corresponding authors: Xiaowei Zheng, email zxw19921212@163.com; Chongke Zhong, email ckzhong@suda.edu.cn
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Abstract

The association between sarcopenia and kidney function remains poorly investigated. We aimed to evaluate the associations between sarcopenia status and kidney function (rapid kidney function decline and chronic kidney disease (CKD)) in middle-aged and older Chinese population. A total of 9375 participants from the China Health and Retirement Longitudinal Study 2011 were included in the cross-sectional analyses. A total of 5864 participants with eGFRcr-cys ≥ 60 ml/min per 1·73 m2 at baseline were included in the longitudinal analyses and were followed up in 2015. Sarcopenia status was defined according to the Asian Working Group for Sarcopenia 2019 criteria. In the cross-sectional analyses, possible sarcopenia and sarcopenia were significantly associated with an increased risk of CKD. During the 4 years of follow-up, 359 (6·12 %) participants experienced rapid decline in kidney function and 126 (2·15 %) participants developed CKD. After multivariable adjustment of baseline eGFRcr-cys level and other risk factors, possible sarcopenia (OR, 1·33; 95 % CI 1·01, 2·12) and sarcopenia (OR, 1·49; 95 % CI 1·05, 2·12) were associated with an increased risk of primary outcome (composite of rapid decline in kidney function (annualised decline in eGFRcr-cys ≥ 5 ml/min per 1·73 m2) and progression to CKD (eGFRcr-cys < 60 ml/min per 1·73 m2). Individuals with low muscle mass or low muscle strength alone also had an increased risk of rapid decline in kidney function and progression to CKD.

Keywords

SarcopeniaPossible sarcopeniaChronic kidney diseaseLow muscle massKidney function decline
Type
Research Article
Information
British Journal of Nutrition , Volume 131 , Issue 5 , 14 March 2024 , pp. 821 - 828
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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