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Changes in plasma fibronectin during acute nutritional deprivation in healthy human subjects

Published online by Cambridge University Press:  09 March 2007

S. J. D. Chadwick ,
A. J. W. Sim  and
H. A. F. Dudley
S. J. D. Chadwick
Affiliation:
Academic Surgical Unit, St Mary's Hospital Medical School, London W2 1PG
A. J. W. Sim
Affiliation:
Academic Surgical Unit, St Mary's Hospital Medical School, London W2 1PG
H. A. F. Dudley
Affiliation:
Academic Surgical Unit, St Mary's Hospital Medical School, London W2 1PG
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Abstract

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1. Plasma fibronectin, a glycoprotein, is an opsonin of the reticuloendothelial system.

2. In ten healthy volunteers starved for 4.5 d, daily measurements showed a rapid reduction in plasma fibronectin, no alteration in either C3 or plasma transferrin and, at the end of the starvation period, an elevated serum albumin.

3. On refeeding, plasma fibronectin rapidly returned to its prestarvation level but plasma transferrin was significantly reduced and did not recover by the end of the study.

4. Changes in plasma fibronectin may be a sensitive index of nutritional status. The reduction of plasma fibronectin in short-term starvation may compromise host defence tolerance of injury and sepsis.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 55 , Issue 1 , January 1986 , pp. 7 - 12
Copyright
Copyright © The Nutrition Society 1986

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