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Changes in serum β-lipoprotein concentration during the development of kwashiorkor and in recovery

Published online by Cambridge University Press:  09 February 2010

W. A. Coward  and
R. G Whitehead
W. A. Coward
Affiliation:
Medical Research Council Child Nutrition Unit, PO Box 6717, Kampala, Uganda
R. G Whitehead
Affiliation:
Medical Research Council Child Nutrition Unit, PO Box 6717, Kampala, Uganda
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Abstract

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1. Serum β-lipoprotein and cholesterol have been measured in children ‘at risk’ to severe protein-calorie malnutrition and in others with kwashiorkor or marasmus. β-Lipoprotein was estimated by an immunological technique. In children recovering from kwashiorkor, serum triglyceride estimations and lipoprotein electrophoretic separations were also carried out.

2. β-Lipoprotein concentrations did not fall significantly until serum albumin concentration was less than 2.5 g/100 ml; cholesterol concentration fell before β-lipoprotein.

3. In frank kwashiorkor, serum β-lipoprotein concentration was reduced by about 30%, whereas cholesterol and triglyceride concentrations were reduced by about 50% in comparison with apparently normal children. Electrophoretic evidence showed that serum α-lipoprotein concentration was also reduced or absent altogether. Marasmic children had normal serum concentrations of β-lipoprotein and the other lipid components measured.

4. The metabolic significance of this degree of reduction in serum β-lipoprotein concentration in the pathogenesis of the fatty liver of kwashiorkor has been discussed. It was concluded that, in Ugandan children with serum albumin concentrations below 2.50 g/100 ml, the β-lipoprotein concentration was probably insufficient for normal mobilization of fat from the liver and the children could therefore be considered susceptible to the development of a fatty liver.

5. The recovery from kwashiorkor was marked by a rapid rise in serum β-lipoprotein concentration and hypertriglyceridaemia but a slower rise in cholesterol concentration. This confirmed the results of previous investigations.

Type
Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 27 , Issue 2 , March 1972 , pp. 383 - 394
Copyright
Copyright © The Nutrition Society 1972

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