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Dietary fructose v. glucose in rats raises urinary excretion, true absorption and ileal solubility of magnesium but decreases magnesium retention

Published online by Cambridge University Press:  09 March 2007

Annet Van Der Heijden
Affiliation:
Department of Laboratory Animal Science, Utrecht University, 3508 TD Utrecht, The Netherlands
Gerrit J. Van Den Berg
Affiliation:
Interfaculty Reactor Institute, University of Technology, 2629 JB Delft, The Netherlands
Arnoldlna G. Lemmens
Affiliation:
Department of Laboratory Animal Science, Utrecht University, 3508 TD Utrecht, The Netherlands
Anton C. Beynen
Affiliation:
Department of Laboratory Animal Science, Utrecht University, 3508 TD Utrecht, The Netherlands
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Abstract

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Apparent Mg absorption, that is Mg intake minus faecal excretion, was found to be greater in rats fed on diets containing fructose instead of glucose. This effect of fructose was accompanied by enhanced urinary excretion and diminished retention of Mg. True Mg absorption was then determined with the use of oral and intraperitoneal administration of tracer doses of 28Mg. True Mg absorption was significantly greater in rats fed on fructose. There was no significant effect of fructose v. glucose on faecal excretion of endogenous Mg. It was hypothesized that fructose enhances the solubility of Mg in the ileal lumen and thereby facilitates its absorption. The distribution of Mg between the solid and liquid phases of the ileum was determined in rats fed on either glucose or fructose. Fructose reduced the amount of Mg in the solid phase but raised both the amount and the concentration of Mg in the liquid phase. We conclude that the dietary-fructose-induced stimulation of Mg absorption in rats is caused by a raised solubility of ileal Mg. but the mechanism by which fructose exerts this effect and why it was not associated with a decrease in faecal excretion of endogenous Mg remain unknown. Dietary fructose v. glucose did not systematically affect the apparent absorption of Ca and P.

Type
Effects of fructose on magnesium absorption and retention
Copyright
Copyright © The Nutrition Society 1994

References

REFERENCES

Barneveld, A. A. & Van den Hamer, C. J. A. (1984) Intestinal passage of simultaneously administered 64Cu and 65Zn and the effect of feeding in mouse and rat. Nutrition Reports International 29, 173182.Google Scholar
Bergstrom, J., Hultman, E. & Roch-Norlund, A. E. (1968). Lactic acid accumulation in connection with fructose infusion. Acta Medica Scandinavica 184, 359364.CrossRefGoogle ScholarPubMed
Brink, E. J. & Beynen, A. C. (1992). Nutrition and magnesium absorption: a review. Progress in Food and Nutrition Science 16, 121162.Google ScholarPubMed
Brink, E. J., Beynen, A. C., Dekker, P. R., Van Beresteijn, E. C. H. & Van der Meer, R. (1992a). Interaction of calcium and phosphate decreases ileal magnesium solubility and apparent magnesium absorption in rats. Journal of Nutrition 122, 580586.CrossRefGoogle ScholarPubMed
Brink, E. J., Van den Berg, G. J., Van der Meer, R., Wolterbeek, H. Th., Dekker, P. R. & Beynen, A. C. (1992b).Inhibitory effect of soybean protein vs. casein on apparent absorption of magnesium in rats is due to greater excretion of endogenous magnesium. Journal of Nutrition 122, 19101916.CrossRefGoogle Scholar
Charley, P. J., Sarkar, B., Stitt, C. F. & Saltman, P. (1963). Chelation of iron by sugars. Biochimica et Biophysics Acta 69, 313321.CrossRefGoogle ScholarPubMed
Hardwick, L. L., Jones, M. R., Brautbar, N. & Lee, D. B. N. (1991). Magnesium absorption: mechanisms and the influence of vitamin D, calcium and phosphate. Journal of Nutrition 121, 1323.CrossRefGoogle ScholarPubMed
Heijnen, A. M. P., Brink, E. J., Lemmens, A. G. & Beynen, A. C. (1993). Ideal pH and apparent absorption of magnesium in rats fed on diets containing either lactose or lactulose. British Journal of Nutrition 70, 747756.CrossRefGoogle ScholarPubMed
Heth, D. A. & Hoekstra, W. G. (1965). Zinc-65 absorption and turnover in rats. Journal of Nutrition 85, 367374.CrossRefGoogle ScholarPubMed
Holbrook, J. T., Smith, J. C. & Reiser, S. (1989). Dietary fructose or starch: effects on copper, zinc, iron, manganese, calcium, and magnesium balances in humans. American Journal of Clinical Nutrition 49, 12901294.CrossRefGoogle ScholarPubMed
Kaup, S. M. & Greger, J. L. (1990). Effect of various chloride salts on the utilization of phosphorus, calcium and magnesium. Journal of Nutritional Biochemistry 1, 542548.CrossRefGoogle ScholarPubMed
McDougal, W. C. & Koch, M. (1989). Effect of sulphate on calcium and magnesium homeostasis following urinary diversion. Kidney International 35, 105115CrossRefGoogle ScholarPubMed
National Research Council (1978). Nutrient Requirements of Laboratory Animals, no. 10, 3rd ed. Washington DC.: National Academy of Sciences.Google Scholar
Sahebjami, H. & Scalettar, R. (1971). Effects of fructose infusion on lactate and uric acid metabolism. Lancet 1, 366369.CrossRefGoogle ScholarPubMed
Shils, M. E. (1988). Magnesium in health and disease. Annual Review of Nutrition 8, 429460.CrossRefGoogle ScholarPubMed
Toothill, J. (1963). The effect of certain dietary factors on the apparent absorption ofmagnesium by the rat. British Journal of Nutrition 17, 125134.CrossRefGoogle Scholar
Vaughan, O. W. & Filer, L. J. (1960). The enhancing action of certain carbohydrates on the intestinal absorption of calcium in the rat. Journal of Nutrition 71, 1014.CrossRefGoogle ScholarPubMed
Wilkinson, R. (1976). Absorption of calcium, phosphorus and magnesium. In: Calcium, Phosphate and Magnesium Metabolism [Nordin, B. E. C., editor]. Edinburgh: Churchill Livingstone.Google Scholar
Woteki, C. E., Welsh, S. O., Raper, W. & Marston, R. M. (1982). Recent trends and levels of dietary sugars and other caloric sweeteners. In: Metabolic Efects of Utilizable Carbohydrates [Reiser, S., editor]. New York, NY: Marcel Dekker.Google Scholar