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Effect of cold exposure on energy balance and liver respiratory capacity in post-weaning rats fed a high-fat diet

Published online by Cambridge University Press:  09 March 2007

Susanna Iossa ,
Lillà Lionetti ,
Maria P. Mollica ,
Raffaella Crescenzo ,
Antonio Barletta  and
Giovanna Liverini
Susanna Iossa
Affiliation:
Department of General and Environmental Physiology, University of Naples‘FEDERICO II’, Italy
Lillà Lionetti
Affiliation:
Department of General and Environmental Physiology, University of Naples‘FEDERICO II’, Italy
Maria P. Mollica
Affiliation:
Department of General and Environmental Physiology, University of Naples‘FEDERICO II’, Italy
Raffaella Crescenzo
Affiliation:
Department of General and Environmental Physiology, University of Naples‘FEDERICO II’, Italy
Antonio Barletta
Affiliation:
Department of General and Environmental Physiology, University of Naples‘FEDERICO II’, Italy
Giovanna Liverini*
Affiliation:
Department of General and Environmental Physiology, University of Naples‘FEDERICO II’, Italy
*
Corresponding author: Professor Giovanna Liverini, fax +39 081 5424 848 email: susiossa@unina.it
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Abstract

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Variations in energy balance, body composition, and nutrient partitioning induced by high-fat feeding, cold exposure or by concomitant high-fat feeding and cold exposure were studied in young Wistar rats. Changes in hepatic metabolism as well as in serum free triiodothyronine and leptin levels were also evaluated. Rats were exposed to either 24 or 4°C and fed either a low- or high-fat diet (10 % or 50 % energy respectively) for 2 weeks. Relative to low-fat feeding at 24°C, both energy intake and expenditure were increased by high-fat feeding or by cold exposure, and these changes were accompanied by increased serum triiodothyronine levels. In response to concomitant high-fat feeding and cold exposure, serum triiodothyronine tended to be further elevated, but no further increases in energy intake or energy expenditure were observed. Independently of diet, the increased energy expenditure in cold-exposed rats was not completely balanced by adaptive hyperphagia, with consequential reductions in protein and fat gain, accompanied by marked decreases in serum leptin. Furthermore, unlike high-fat feeding at 24°C, cold exposure enhanced hepatic mitochondrial oxidative capacity both in the low-fat- and high-fat-fed groups. It is concluded that in this strain of young Wistar rats, despite similarly marked stimulation of energy expenditure by high-fat feeding at 24°C, by cold exposure and by concomitant high-fat feeding and cold exposure, an increased hepatic oxidative capacity occurred only in the presence of the cold stimulus.

Keywords

Body compositionNutrient partitioningTriiodothyronineLeptin
Type
Research Article
Information
British Journal of Nutrition , Volume 85 , Issue 1 , January 2001 , pp. 89 - 96
Copyright
Copyright © The Nutrition Society 2001

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