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Effect of neonatal undernutrition on serum follicle-stimulating hormone levels and ovarian development in the female rat

Published online by Cambridge University Press:  09 March 2007

P. E. Schenck ,
A. Koos Slob ,
J. TH. J. Uilenbroek  and
J. J. Van Der Werff Ten Bosch
P. E. Schenck
Affiliation:
Department of Endocrinology, Growth and Reproduction, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands
A. Koos Slob
Affiliation:
Department of Endocrinology, Growth and Reproduction, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands
J. TH. J. Uilenbroek
Affiliation:
Department of Endocrinology, Growth and Reproduction, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands
J. J. Van Der Werff Ten Bosch
Affiliation:
Department of Endocrinology, Growth and Reproduction, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands
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Abstract

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1. Female rats were undernourished from birth through replacement for 12 h/d of the lactating mother by a nipple-ligated mother. This resulted in slow growth so that at 22 d of age the body-weights equalled those of well-nourished animals at 14 d.

2. At 14, 17, 20 and 22 d groups of eight to ten animals each of undernourished and well-nourished rats were autopsied, serum follicle-stimulating hormone (FSH) concentration was determined by radioimmunoassay, utersuses were weighed and ovaries examined by light microscopy.

3. Undernutrition caused a 3–4 d delay in the third-week drop in serum FSH and in ovarian development as indicated by the number of antral follicles and by the maximal diameter of the ovaries and of the largest follicles.

4. It is postulated that the effect of undernutrition on serum FSH may be due to delayed increase in ovarian feedback effectiveness, which may be the result of either the retardation in ovarian development or a continued high level of serum oestrogen-binding protein. It remains uncertain through which mechanism(s) undernutrition brings about delayed onset of puberty.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 44 , Issue 2 , September 1980 , pp. 179 - 182
Copyright
Copyright © The Nutrition Society 1980

References

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