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Effect of potassium salts in rats adapted to an acidogenic high-sulfur amino acid diet

Published online by Cambridge University Press:  08 March 2007

Houda Sabboh ,
Marie-Noëlle Horcajada ,
Véronique Coxam ,
Jean-Claude Tressol ,
Catherine Besson ,
Christian Rémésy  and
Christian Demigné
Houda Sabboh
Affiliation:
Unité des Maladies Métaboliques et Micronutriments, INRA de Clermont-Ferrand/Theix and CRNH d'Auvergne, 63122, St-Genès-Champanelle, France
Marie-Noëlle Horcajada
Affiliation:
Unité des Maladies Métaboliques et Micronutriments, INRA de Clermont-Ferrand/Theix and CRNH d'Auvergne, 63122, St-Genès-Champanelle, France
Véronique Coxam
Affiliation:
Unité des Maladies Métaboliques et Micronutriments, INRA de Clermont-Ferrand/Theix and CRNH d'Auvergne, 63122, St-Genès-Champanelle, France
Jean-Claude Tressol
Affiliation:
Unité des Maladies Métaboliques et Micronutriments, INRA de Clermont-Ferrand/Theix and CRNH d'Auvergne, 63122, St-Genès-Champanelle, France
Catherine Besson
Affiliation:
Unité des Maladies Métaboliques et Micronutriments, INRA de Clermont-Ferrand/Theix and CRNH d'Auvergne, 63122, St-Genès-Champanelle, France
Christian Rémésy
Affiliation:
Unité des Maladies Métaboliques et Micronutriments, INRA de Clermont-Ferrand/Theix and CRNH d'Auvergne, 63122, St-Genès-Champanelle, France
Christian Demigné*
Affiliation:
Unité des Maladies Métaboliques et Micronutriments, INRA de Clermont-Ferrand/Theix and CRNH d'Auvergne, 63122, St-Genès-Champanelle, France
*
*Corresponding author: Dr C. Demigné, fax +33 473 624638, email demigne@clermont.inra.fr
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Abstract

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Low-grade metabolic acidosis, consecutive to excessive catabolism of sulfur amino acids and a high dietary Na:K ratio, is a common feature of Western food habits. This metabolic alteration may exert various adverse physiological effects, especially on bone, muscle and kidneys. To assess the actual effects of various K salts, a model of the Westernised diet has been developed in rats: slight protein excess (20 % casein); cations provided as non-alkalinising salts; high Na:K ratio. This diet resulted in acidic urine (pH 5·5) together with a high rate of divalent cation excretion in urine, especially Mg. Compared with controls, K supplementation as KCl accentuated Ca excretion, whereas potassium bicarbonate or malate reduced Mg and Ca excretion and alkalinised urine pH (up to 8). In parallel, citraturia was strongly increased, together with 2-ketoglutarate excretion, by potassium bicarbonate or malate in the diet. Basal sulfate excretion, in the range of 1 mmol/d, was slightly enhanced in rats fed the potassium malate diet. The present model of low-grade metabolic acidosis indicates that potassium malate may be as effective as KHCO3 to counteract urine acidification, to limit divalent cation excretion and to ensure high citrate concentration in urine.

Keywords

Low-grade acidosisPotassiumMagnesiumMalateSulfate
Type
Research Article
Information
British Journal of Nutrition , Volume 94 , Issue 2 , August 2005 , pp. 192 - 197
Copyright
Copyright © The Nutrition Society 2005

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