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The effects of dietary calcium and phosphorus on the retention and excretion of lead in rats

Published online by Cambridge University Press:  09 March 2007

J. Quarterman  and
J. N. Morrison
J. Quarterman
Affiliation:
The Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
J. N. Morrison
Affiliation:
The Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
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Abstract

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1. Rats were given diets containing different amounts of calcium, phosphorus and lead.

2. Pb retention was greatly increased when the diets contained less Ca or P than the minimum estimated requirement of the rat.

3. The release of Pb already incorporated into the skeleton was inhibited by diets low in Ca but was not affected by diets low in P.

4. The retention of Pb given intraperitoneally was not affected by dietary Ca or P.

5. It can be concluded that dietary Ca and P influence the absorption of Pb by the gut and dietary Ca influences the metabolism of Pb in the bone.

6. There were changes in the distribution of Pb among the tissues due to changes of dietary Ca.

7. At low body concentrations, Pb probably affected skeletal growth.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 34 , Issue 3 , November 1975 , pp. 351 - 362
Copyright
Copyright © The Nutrition Society 1975

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