Hostname: page-component-5c6d5d7d68-xq9c7 Total loading time: 0 Render date: 2024-08-16T07:01:01.019Z Has data issue: false hasContentIssue false
  • English
  • Français

The importance of the non-protein components of the diet in the plasma cholesterol response of rabbits to casein

Published online by Cambridge University Press:  09 March 2007

E. C. Allotta ,
S. Samman  and
D. C. K. Roberts
E. C. Allotta
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
S. Samman
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
D. C. K. Roberts
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. To characterize the hypercholesterolaemic effect of casein further, four groups of young male rabbits in two separate experiments were placed on cholesterol-free semi-purified diets for 12 weeks. The diets were similar in composition, with either casein or soya-bean-protein isolate providing the protein source (250 g/kg). In two of these diets the salt mix was reduced by 45% (normally 40 g/kg) and replaced by potassium bicarbonate.

2. Growth was unaffected by these alterations in dietary salts except for one group given the soya-bean-reduced-salts diet.

3. The mean concentrations of plasma cholesterol were significantly higher in all casein-fed groups as compared with their soya-bean-fed counterparts but the response was much greater in those given the casein—reduced-salts diet.

4. Contrary to expectations, analysis of the diets showed the zinc and copper concentrations of the casein diets to be less than those of the soya-bean diets. This was due to the greater concentrations of Cu (threefold) and Zn (twofold) in the soya-bean-protein isolate compared with casein.

5. The mean concentration of Zn in fur was significantly decreased in casein-fed rabbits and these animals also excreted less Zn but more Cu in their urine than those given the casein—reduced-salts diet.

6. The rabbits given the casein diet with the least salt mix showed the greatest degree of hypercholesterolaemia, suggesting an interaction between trace elements and the casein effect.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 54 , Issue 1 , July 1985 , pp. 87 - 94
Copyright
Copyright © The Nutrition Society 1985

References

Allen, K. G. D. & Klevay, L. M. (1978). Atherosclerosis 31, 259–271.CrossRefGoogle Scholar
Beynen, A. C. & van Wanrooy-Stroeken, C. T. M. (1981). Zeitschfirt für Tierphysiologie, Tierernährung und Futtermittelkunde 46, 240–246.CrossRefGoogle Scholar
Beynen, A. G. & West, C. E. (1981). Zeitschrift für Tierephysiologie, Tierernährung und Futtermittelkunde 46, 233–239.CrossRefGoogle Scholar
Carroll, K. K. (1971). Atherosclerosis 13, 67–76.CrossRefGoogle Scholar
Carroll, K. K. & Hamilton, R. M. G. (1975). Journal of Food Science 40, 18–23.CrossRefGoogle Scholar
Harvey, P. W. & Allen, K. G. D. (1981). Journal of Nutrition 111, 1855–1858.CrossRefGoogle Scholar
Hermus, R. J. J. (1975). Experimental Atherosclerosis in Rabbits on Diets with Milk Fat and Different Proteins. Wageningen; The Netherlands: Centre for Agricultural Publishing and Documentation.Google Scholar
Huff, M. W. & Carroll, K. K. (1980). Journal of Nutrition 110, 1676–1686.CrossRefGoogle Scholar
Huff, M. W., Hamilton, R. M. G. & Carroll, K. K. (1977). Atherosclerosis 28, 187–195.CrossRefGoogle Scholar
Klevay, L. M. (1973). American Journal of Clinical Nutrition 26, 1060–1068.CrossRefGoogle Scholar
Kritchevsky, D. (1979). Journal of the American Oil Chemists Society 56, 135–140.CrossRefGoogle Scholar
Lacombe, C. & Nibbelink, M. (1980). Artery 6, 280–289.Google Scholar
Lau, B. W. C. & Klevay, L. M. (1982). Journal of Nutrition 112, 928–933.CrossRefGoogle Scholar
Mckenzie, J. M. (1978). American Journal of Clinical Nutrition 31, 470–476.CrossRefGoogle Scholar
Mann, G. V. (1961). Clinical Chemistry 7, 275–284.CrossRefGoogle Scholar
Meret, S. & Henkin, R. I. (1971). Clinical Chemistry 17, 369–373.CrossRefGoogle Scholar
Roberts, D. C. K. (1981). In Festschrift for Courtice F. C., pp. 130–138 [Garlic, D., editor]. NSW, Australia: The University of New South Wales, School of Physiology and Pharmacology.Google Scholar
Snedecor, G. W. & Cochran, W. G. (1968). Statistical Methods, 6th ed., p. 484. Ames: Iowa State University Press.Google Scholar
Terpstra, A. H. M. & Sanchez-Muniz, F. J. (1981). Atherosclerosis 39, 217–227.CrossRefGoogle Scholar
Terpstra, A. H. M., Woodward, C. J. H., West, C. E. & Van Boven, H. G. (1982). British Journal of Nutrition 47, 213–221.CrossRefGoogle Scholar
West, C. E., Deuring, K., Schutte, J. B. & Terpstra, A. H. M. (1982). Journal of Nutrition 112, 1287–1295.CrossRefGoogle Scholar
Wigand, G. (1959). Acta Medica Scandinavica 166, 1–91.Google Scholar
Zlatkis, A. & Zak, B. (1969). Analytical Biochemistry 29, 143–148.CrossRefGoogle Scholar