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Inability of selenium to affect creatine metabolism in rat muscle*

Published online by Cambridge University Press:  09 March 2007

A. J. Barak ,
T. B. Allison ,
D. J. Tuma  and
M. F. Sorrell
A. J. Barak
Affiliation:
Liver Study Unit, Veterans Administration Hospital, Division of Cardiology, Department of Internal Medicine, and Department of Biochemistry, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
T. B. Allison
Affiliation:
Liver Study Unit, Veterans Administration Hospital, Division of Cardiology, Department of Internal Medicine, and Department of Biochemistry, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
D. J. Tuma
Affiliation:
Liver Study Unit, Veterans Administration Hospital, Division of Cardiology, Department of Internal Medicine, and Department of Biochemistry, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
M. F. Sorrell
Affiliation:
Liver Study Unit, Veterans Administration Hospital, Division of Cardiology, Department of Internal Medicine, and Department of Biochemistry, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
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Abstract

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1. Two groups of adult rats were placed in a metal-free environment and pair-fed with selenium-supplemented and Se-deficient diets.

2. After 5 months the animals were killed and skeletal muscle concentrations of creatine, creatine phosphate, ATP, protein and Se were determined.

3. Se deficiency was indicated by the low Se content of the skeletal muscle from the deficient animals, but no changes were found in the amounts of the other components.

4. These results suggest that Se may not be involved in creatine metabolism and that Se deficiency may not be concerned independently in the development of nutritional dystrophy, where changes are found in the levels of protein, creatine, creatine phosphate and ATP.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 34 , Issue 1 , July 1975 , pp. 119 - 123
Copyright
Copyright © The Nutrition Society 1975

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