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Lactobacillus gasseri: effects on mouse intestinal flora enzyme activity and isoflavonoids in the caecum and plasma

Published online by Cambridge University Press:  09 March 2007

Motoi Tamura ,
Mayumi Ohnishi-Kameyama  and
Kazuki Shinohara
Motoi Tamura*
Affiliation:
National Food Research Institute, Tsukuba 305-8642, Japan
Mayumi Ohnishi-Kameyama
Affiliation:
National Food Research Institute, Tsukuba 305-8642, Japan
Kazuki Shinohara
Affiliation:
National Food Research Institute, Tsukuba 305-8642, Japan
*
*Corresponding author: Dr Motoi Tamura, fax +81 298 38 7996, email, motoita@nfri.affrc.go.jp
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Abstract

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The effects of Lactobacillus gasseri JCM 1131T on isoflavonoid levels within the caecum and plasma were assessed in adult mice. Male 5-week-old mice were fed an AIN 93M diet for 30 d. Two groups of mice were administered either L. gasseri JCM 1131T (the LGI group) or physiological saline solution (the control (CI) group) daily for 5 d before dissection. The plasma daidzein concentration was significantly higher in the LGI group, however, their plasma equol concentration was significantly less than in the CI group. The total amount of equol present as aglycone in the caecum was significantly greater in the CI group, but there was no significant difference in the total daidzein present as caecal aglycone. In an in vitro incubation of daidzin with the faecal flora of mice, the equol concentration was significantly higher in the CI group. The numbers of lactobacilli present were significantly higher in the LGI group. The present data suggest that the administration of L. gasseri is likely to influence the effect of isoflavonoids on the host via changes in the gastrointestinal environment.

Keywords

DaidzeinEquolLactobacillus gasseriCaecal enzyme activity
Type
Research Article
Information
British Journal of Nutrition , Volume 92 , Issue 5 , November 2004 , pp. 771 - 776
Copyright
Copyright © The Nutrition Society 2004

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