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Nucleotides as semiessential nutritional components

Published online by Cambridge University Press:  09 March 2007

A. Sánchez-Pozo  and
A. Gil
A. Sánchez-Pozo*
Affiliation:
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain
A. Gil
Affiliation:
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain
*
*Corresponding author: Dr A. Sánchez-Pozo, fax +34 958 248 960, email sanchezp@platon.ugr.es
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Abstract

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Type
Research Article
Information
British Journal of Nutrition , Volume 87 , Issue S1 , January 2002 , pp. S135 - S137
Copyright
Copyright © The Nutrition Society 2002

References

Bueno, J, Torres, M, Almendros, A, Carmona, R, Núñez, MC, Ríos, A & Gil, A (1994) Effect of dietary nucleotides on small intestinal repair after diarrhea. Histological and ultrastructural changes. Gut 35, 926–933.CrossRefGoogle ScholarPubMed
Carver, JD (1994) Dietary nucleotides: cellular immune, intestinal and hepatic system effects. Journal of Nutrition 124, 144S–148S.CrossRefGoogle ScholarPubMed
Carver, JD (1999) Dietary nucleotides: effects on the immune and gastrointestinal systems. Acta Paediatrica 88, 83S–88S.CrossRefGoogle ScholarPubMed
Felipe, A, Ferrer-Martínez, A, Casado, FJ & Pastor-Anglada, M (1997) Expression of the sodium-dependent purine nucleoside carrier (SPNT) mRNA correlates with nucleoside transport activity in rat liver. Biochemical and Biophysical Research Communications 233, 572–575.CrossRefGoogle ScholarPubMed
Jackson, CD, Weis, C, Miller, BJ & James, SJ (1997) Dietary nucleotides: effects on cell proliferation following partial hepatectomy in rats fed NIH-31, AIN-76A or folate/methyl-deficient diets. Journal of Nutrition 127, 834S–837S.CrossRefGoogle ScholarPubMed
Leleiko, NS, Bronstein, AD, Baliga, BS & Munro, HN (1983) De novo purine synthesis in the rat small and large intestine: effect of dietary protein and purines. Journal of Pediatric Gastroenterology and Nutrition 2, 313–319.CrossRefGoogle ScholarPubMed
López-Navarro, AT, Gil, A & Sánchez-Pozo, A (1995) Deprivation of dietary nucleotides results in a transient decrease in acid-soluble nucleotides and RNA concentration in rat liver. Journal of Nutrition 125, 2090–2095.CrossRefGoogle Scholar
López-Navarro, AT, Bueno, JD, Gil, A & Sánchez-Pozo, A (1996a) Morphological changes in hepatocytes of rats deprived of dietary nucleotides. British Journal of Nutrition 76, 579–589.CrossRefGoogle ScholarPubMed
López-Navarro, AT, Ortega, MA, Peragón, J, Bueno, JD, Gil, A & Sánchez-Pozo, A (1996b) Deprivation of dietary nucleotides decreases protein synthesis in the liver and small intestine of rats. Gastroenterology 110, 1760–1769.CrossRefGoogle Scholar
Martínez-Augustin, O, Boza, JJ, del Pino, JI, Lucena, J, Martínez-Valverde, A & Gil, A (1997) Dietary nucleotides might influence immune response against cow’s milk proteins in preterm neonates. Biology of the Neonate 71, 215–223.CrossRefGoogle ScholarPubMed
Morillas, J, Moltó, L, Robles, R, Gil, A & Sánchez-Pozo, A (1994) Lipoprotein changes in small-for gestational-age infants fed nucleotide supplemented milk formula. Acta Paediatrica 83, 481–485.CrossRefGoogle ScholarPubMed
Navarro, J, Ruiz-Bravo, A, Jiménez-Valera, M & Gil, A (1996) Modulation of antibody-forming cell and mytogen-driven lymphoproliferative responses by dietary nucleotides in mice. Immunology Letters 53, 141–145.CrossRefGoogle ScholarPubMed
Navarro, J, Maldonado, J, Ruiz-Bravo, A, García-Salmerón, JL, Molina, JA & Gil, A (1999) Influence of dietary nucleotides on plasma immunoglobulin levels and lymphocyte subsets of preterm infants. Biofactors 10, 67–76.CrossRefGoogle ScholarPubMed
Nuñez, MC, Ayudarte, MV, Morales, D, Suárez, MD & Gil, A (1990) Effect of dietary nucleotides on intestinal repair in rats with experimental chronic diarrhea. Journal of Parenteral and Enteral Nutrition 14, 598–604.CrossRefGoogle ScholarPubMed
Ortega, MA, Gil, A & Sánchez-Pozo, A (1995a) Maturation status of small intestine epithelium in rats deprived of dietary nucleotides. Life Sciences 56, 1623–1630.CrossRefGoogle ScholarPubMed
Ortega, MA, Núñez, MC, Gil, A & Sánchez-Pozo, A (1995b) Dietary nucleotides accelerate intestinal recovery after food deprivation in old rats. Journal of Nutrition 125, 2090–2095.Google ScholarPubMed
Perignon, JL, Bories, DM, Houllier, AM, Thuillier, L & Cartier, PH (1987) Metabolism of pyrimidine bases and nucleosides by pyrimidine-nucleoside phosphorilases in cultured human lymphoid cells. Biochimica et Biophysica Acta 928, 130–136.CrossRefGoogle ScholarPubMed
Rueda, R & Gil, A (2000) Influence of dietary compounds on intestinal immunity. Microbial Ecology Health Diseases 2, 146S–156S.Google Scholar
Sánchez-Pozo, A, Morillas, J, Moltó, L, Robles, R & Gil, A (1994) Dietary nucleotides influence lipoprotein metabolism in newborn infants. Pediatric Research 35, 112–116.CrossRefGoogle ScholarPubMed
Sánchez-Pozo, A, Ramírez, M, Maldonado, J, Gil, A, Van Vierlviet, JP & Rosseneu, M (1995) Dietary nucleotides enhance plasma lecithin cholesterol acyl transferase activity and apolipoprotein A-IV concentration in preterm newborn infants. Pediatric Research 37, 328–333.CrossRefGoogle ScholarPubMed
Sánchez-Pozo, A, Rueda, R, Fontana, L & Gil, A (1998) Dietary Nucleotides and cell growth. Trends in Comparative Biochemistry and Physiology 5, 99–111.Google Scholar
Torres, MI, Fernández, MI, Gil, A & Rios, A (1997) Effect of dietary nucleotides on degree of fibrosis and steatosis induced by oral intake of thioacetamide. Digestive Disease Sciences 42, 1322–1328.CrossRefGoogle ScholarPubMed
Tsujinaka, T, Kishibuchi, M, Iijima, S, Yano, M & Monden, M (1997) Role of supplementation of a nucleic acid solution on the intestinal mucosa under total parenteral nutrition. Nutrition 13, 369–371.CrossRefGoogle ScholarPubMed
Uauy, R (1989) Dietary nucleotides and requirements in early life. In Textbook of Gastroeneterology and Nutrition in Infancy, pp. 265–280 [Lebenthal, E editor]. New York, NY: Raven Press.Google Scholar
Uauy, R, Quan, R & Gil, A (1994) Role of nucleotides in intestinal development and repair: implications for infant nutrition. Journal of Nutrition 124, 1436S–1441S.CrossRefGoogle ScholarPubMed
Valdés, R, Ortega, MA, Casado, FJ, Felipe, A, Gil, A, Sánchez-Pozo, A & Pastor-Anglada, M (2000) Nutritional regulation of nucleoside transporter expression in rat small intestine. Gastroenterology 119, 1623–1630.CrossRefGoogle ScholarPubMed
Van Buren, CT & Rudolph, F (1997) Dietary nucleotides: a conditional requirement. Nutrition 13, 470–472.CrossRefGoogle ScholarPubMed
Walsh, MJ, Sánchez-Pozo, A & Leleiko, NS (1990) A regulatory element is characterized by purine-mediated and cell-type-specific gene transcription. Molecular Cell Biology 10, 4356–4364.Google ScholarPubMed
Walsh, MJ, Tsao, KL & Leleiko, NS (1992) Characterization of DNA-protein interactions within a distal regulatory element upstream of a mammalian housekeeping gene promoter. Journal of Biological Chemistry 267, 7026–7035.CrossRefGoogle ScholarPubMed
Yamamoto, S, Wang, MF, Adjei, AA & Ameho, CK (1997) Role of nucleosides and nucleotides in the immnune system, gut reparation after injury, and brain function. Nutrition 13, 372–374.CrossRefGoogle Scholar
Yamaoka, T, Kondo, M, Honda, S, Iwahana, H, Moritani, M, Ii, S, Yoshimoto, K & Itakura, M (1997) Amidophosphoribosyltransferase limits the rate of cell growth-linked de novo purine biosynthesis in the presence of constant capacity of salvage purinebiosynthesis. Journal of Biological Chemistry 272, 17719–17725.CrossRefGoogle Scholar