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Re-exploration of dietary iodine intake in Chinese adult males using a modified iodine balance study

Published online by Cambridge University Press:  06 March 2023

Xiaobing Liu Open the ORCID record for Xiaobing Liu [Opens in a new window] ,
Jun Wang ,
Yajie Li Open the ORCID record for Yajie Li [Opens in a new window] ,
Hongxing Tan ,
Xiuwei Li ,
Deqian Mao ,
Yanyan Liu ,
Weidong Li ,
Wei Yu  and
Jiaxi Lu
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Xiaobing Liu
Affiliation:
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing 100050, People’s Republic of China Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong 518020, People’s Republic of China
Jun Wang
Affiliation:
Shenzhen Polytechnic, School of Food and Drug, Shenzhen, Guangdong 518055, People’s Republic of China
Yajie Li
Affiliation:
Changzhi Medical College, Changzhi, Shanxi 046000, People’s Republic of China
Hongxing Tan
Affiliation:
Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong 518020, People’s Republic of China
Xiuwei Li
Affiliation:
Chinese Center for Disease Control and Prevention, National Reference Laboratory for Iodine Deficiency Disorders, Beijing 100050, People’s Republic of China
Deqian Mao
Affiliation:
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing 100050, People’s Republic of China
Yanyan Liu
Affiliation:
Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong 518020, People’s Republic of China
Weidong Li
Affiliation:
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing 100050, People’s Republic of China
Wei Yu
Affiliation:
Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong 518020, People’s Republic of China
Jiaxi Lu
Affiliation:
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing 100050, People’s Republic of China
Junan Yan
Affiliation:
Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong 518020, People’s Republic of China
Jianhua Piao
Affiliation:
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing 100050, People’s Republic of China
Lichen Yang
Affiliation:
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing 100050, People’s Republic of China
Chongzheng Guo*
Affiliation:
Changzhi Medical College, Changzhi, Shanxi 046000, People’s Republic of China
Xiaoli Liu*
Affiliation:
Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong 518020, People’s Republic of China
Xiaoguang Yang*
Affiliation:
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing 100050, People’s Republic of China Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong 518020, People’s Republic of China
*
*Corresponding authors: Xiaoguang Yang, email xgyangcdc@163.com; Xiaoli Liu, email liuxl36@126.com; Chongzheng Guo, email gczmed@126.com
*Corresponding authors: Xiaoguang Yang, email xgyangcdc@163.com; Xiaoli Liu, email liuxl36@126.com; Chongzheng Guo, email gczmed@126.com
*Corresponding authors: Xiaoguang Yang, email xgyangcdc@163.com; Xiaoli Liu, email liuxl36@126.com; Chongzheng Guo, email gczmed@126.com
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Abstract

There is still controversy about optimal dietary iodine intake as the Universal Salt Iodization policy enforcement in China. A modified iodine balance study was thus conducted to explore the suitable iodine intake in Chinese adult males using the iodine overflow hypothesis. In this study, thirty-eight apparently healthy males (19·1 (sd 0·6) years) were recruited and provided with designed diets. After the 14-d iodine depletion, daily iodine intake gradually increased in the 30-d iodine supplementation, consisting of six stages and each of 5 d. All foods and excreta (urine, faeces) were collected to examine daily iodine intake, iodine excretion and the changes of iodine increment in relation to those values at stage 1. The dose–response associations of iodine intake increment with excretion increment were fitted by the mixed effects models, as well as with retention increment. Daily iodine intake and excretion were 16·3 and 54·3 μg/d at stage 1, and iodine intake increment increased from 11·2 μg/d at stage 2 to 118·0 μg/d at stage 6, while excretion increment elevated from 21·5 to 95·0 μg/d. A zero iodine balance was dynamically achieved as 48·0 μg/d of iodine intake. The estimated average requirement and recommended nutrient intake were severally 48·0 and 67·2 μg/d, which could be corresponded to a daily iodine intake of 0·74 and 1·04 μg/kg per d. The results of our study indicate that roughly half of current iodine intakes recommendation could be enough in Chinese adult males, which would be beneficial for the revision of dietary reference intakes.

Keywords

Iodine requirementZero iodine balanceIodine overflow hypothesisDietary reference intakesMixed effects models
Type
Research Article
Information
British Journal of Nutrition , Volume 130 , Issue 8 , 28 October 2023 , pp. 1308 - 1315
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

†

These authors equally contributed to this work

References

Zimmermann, MB (2011) The role of iodine in human growth and development. Semin Cell Dev Biol 22, 645–652.CrossRefGoogle ScholarPubMed
Lazarus, JH (2015) The importance of iodine in public health. Environ Geochem Health 37, 605–618.CrossRefGoogle ScholarPubMed
Zimmermann, MB (2009) Iodine deficiency. Endocr Rev 30, 376–408.CrossRefGoogle ScholarPubMed
Patriota, ESO, Lima, ICC, Nilson, EAF, et al. (2021) Prevalence of insufficient iodine intake in pregnancy worldwide: a systematic review and meta-analysis. Eur J Clin Nutr 76, 703–715.CrossRefGoogle ScholarPubMed
Pearce, EN, Lazarus, JH, Moreno-Reyes, R, et al. (2016) Consequences of iodine deficiency and excess in pregnant women: an overview of current knowns and unknowns. Am J Clin Nutr 104, 918S–923S.CrossRefGoogle Scholar
Liu, L, Liu, P, Lin, Q, et al. (2021) Iodine nutrition status of women after 10 years of Lipiodol supplementation: a cross-sectional study in Xinjiang, China. Br J Nutr 126, 9–21.CrossRefGoogle ScholarPubMed
Li, Y, Teng, D, Ba, J, et al. (2020) Efficacy and safety of long-term universal salt iodization on thyroid disorders: epidemiological evidence from 31 Provinces of Mainland China. Thyroid 30, 568–579.CrossRefGoogle ScholarPubMed
Du, Y, Gao, Y, Meng, F, et al. (2014) Iodine deficiency and excess coexist in China and induce thyroid dysfunction and disease: a cross-sectional study. PLoS One 9, e111937.CrossRefGoogle Scholar
Farebrother, J, Zimmermann, MB & Andersson, M (2019) Excess iodine intake: sources, assessment, and effects on thyroid function. Ann N Y Acad Sci 1446, 44–65.CrossRefGoogle ScholarPubMed
Teng, W, Shan, Z, Teng, X, et al. (2006) Effect of iodine intake on thyroid diseases in China. N Engl J Med 354, 2783–2793.CrossRefGoogle ScholarPubMed
Song, J, Zou, SR, Guo, CY, et al. (2016) Prevalence of thyroid nodules and its relationship with iodine status in shanghai: a population-based study. Biomed Environ Sci 29, 398–407.Google ScholarPubMed
Karwowska, P & Breda, J (2017) The role of the World Health Organization in eliminating iodine deficiency worldwide. Recent Pat Endocr Metab Immune Drug Discov 10, 138–142.CrossRefGoogle ScholarPubMed
Costa, A, Bacci, R, Campagnoli, C, et al. (1969) Iodine balance studies in pregnancy. Folia Endocrinol 22, 364–372.Google ScholarPubMed
Dold, S, Zimmermann, MB, Baumgartner, J, et al. (2016) A dose-response crossover iodine balance study to determine iodine requirements in early infancy. Am J Clin Nutr 104, 620–628.CrossRefGoogle ScholarPubMed
Vought, RL & London, WT (1967) Iodine intake, excretion and thyroidal accumulation in healthy subjects. J Clin Endocrinol Metab 27, 913–919.CrossRefGoogle ScholarPubMed
Hays, MT (2001) Estimation of total body iodine content in normal young men. Thyroid 11, 671–675.CrossRefGoogle ScholarPubMed
Wang, J, Zhang, H, Mao, D, et al. (2022) Exploration of the lower threshold of iodine intake in Southern Chinese young adults based on ‘overflow theory’ in an iodine balance study. Nutr J 21, 35.CrossRefGoogle Scholar
Yang, L, Wang, J, Yang, J, et al. (2020) An iodine balance study to explore the recommended nutrient intake of iodine in Chinese young adults. Br J Nutr 124, 1156–1165.CrossRefGoogle ScholarPubMed
World Medical A (2013) World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 310, 2191–2194.CrossRefGoogle Scholar
Machado, A, Lima, L, Mesquita, RBR, et al. (2017) Improvement of the Sandell-Kolthoff reaction method (ammonium persulfate digestion) for the determination of iodine in urine samples. Clin Chem Lab Med 55, e206–e208.CrossRefGoogle ScholarPubMed
Chromy, V, Rozkosna, K & Sedlak, P (2008) Determination of serum creatinine by Jaffe method and how to calibrate to eliminate matrix interference problems. Clin Chem Lab Med 46, 1127–1133.CrossRefGoogle ScholarPubMed
Medicine Io (2001) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academies Press (US).Google Scholar
WHO/UNICEF/ICCIDD (2007) Assessment of Iodine Deficiency Disorders and Monitoring their Elimination: a Guide for Programme Managers, 3rd ed. Geneva: WHO.Google Scholar
Liu, T, Li, Y, Teng, D, et al. (2021) The characteristics of iodine nutrition status in China after 20 years of universal salt iodization: an epidemiology study covering 31 provinces. Thyroid 31, 1858–1867.CrossRefGoogle Scholar
Shan, Z, Chen, L, Lian, X, et al. (2016) Iodine status and prevalence of thyroid disorders after introduction of mandatory universal salt iodization for 16 years in China: a cross-sectional study in 10 cities. Thyroid 26, 1125–1130.CrossRefGoogle Scholar
Yao, J, Zhang, W, Wang, J, et al. (2022) The status of iodine nutrition after removing iodized salt in high water iodine regions: a cross-sectional study in China. Biol Trace Elem Res 200, 1020–1031.CrossRefGoogle ScholarPubMed
Malvaux, P, Beckers, C & De Visscher, M (1969) Iodine balance studies in nongoitrous children and in adolescents on low iodine intake. J Clin Endocrinol Metab 29, 79–84.CrossRefGoogle ScholarPubMed
Tan, L, Tian, X, Wang, W, et al. (2019) Exploration of the appropriate recommended nutrient intake of iodine in healthy Chinese wo men: an iodine balance experiment. Br J Nutr 121, 519–528.CrossRefGoogle Scholar
Harrison, MT (1968) Iodine balance in man. Postgrad Med J 44, 69–71.CrossRefGoogle ScholarPubMed
Ingenbleek, Y & Malvaux, P (1974) Iodine balance studies in protein-calorie malnutrition. Arch Dis Child 49, 305–309.CrossRefGoogle ScholarPubMed
Society CN (2013) Chinese DRIs Handbook. Beijing: Standards Press of China.Google Scholar
Thomson, CD (2004) Selenium and iodine intakes and status in New Zealand and Australia. Br J Nutr 91, 661–672.CrossRefGoogle Scholar
Mackerras, DE & Eastman, CJ (2012) Estimating the iodine supplementation level to recommend for pregnant and breastfeeding women in Australia. Med J Aust 197, 238–242.CrossRefGoogle ScholarPubMed
Zimmermann, M & Delange, F (2004) Iodine supplementation of pregnant women in Europe: a review and recommendations. Eur J Clin Nutr 58, 979–984.CrossRefGoogle Scholar