Hostname: page-component-7479d7b7d-k7p5g Total loading time: 0 Render date: 2024-07-12T14:34:11.715Z Has data issue: false hasContentIssue false
  • English
  • Français

Regulation of food intake during growth in fatty and lean female Zucker rats given diets of different protein content

Published online by Cambridge University Press:  09 March 2007

J. D. Radcliffe  and
A. J. F. Webster
J. D. Radcliffe
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
A. J. F. Webster
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Food intake, and the rates of protein, lipid and energy deposition during growth were measured for lean and congenitally obese (fatty) female Zucker rats given diets of different protein content ad lib. Six semi-synthetic diets were used, which contained 40, 100, 150, 300, 500 and 700 g casein/kg (diets 40C, 100C, 150C, 300C, 500C and 700C).

2. Dietary treatments began when the rats were 34 or 35 d old. Collections of urine and faeces were analysed for energy content. The total carcasses of all the rats were analysed individually for protein, lipid and energy.

3. In the first experiment, twelve rats of each phenotype were given diets 150C or 300C. Four fatty and four lean rats were killed at 50, 66 and 98 d of age. In the second experiment groups of four fatty and four lean rats were given diets 40C, 100C, 500C and 700C ad lib. until they were killed at 66 d of age. Other groups of fatty rats were pair-fed from 35 to 67 d of age on diets 100C and 500C. Rats were also killed at 24 and 34 d of age to provide initial samples for the comparative slaughter procedure.

4. When given food ad lib., fatty and lean rats had identical rates of protein deposition at all ages and for all diets, but lipid and energy deposition were always much greater in the fatty rats. Food intake was also much greater for the fatty rats (except on diet 40C). Differences in food intake and growth rate attributable to diet were most pronounced for the range of diets 40C-150C.

5. Fatty rats pair-fed to lean rats deposited less protein but about twice as much energy and lipid as lean rats on the same diets.

6. The results are discussed in relation to existing theories of appetite control. It appears that food intake is precisely regulated in the congenitally obese Zucker rat. This regulation is intimately linked with the impetus for protein deposition and the rates of retention of lipid and energy appear to be of no importance in relation to appetite control.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 36 , Issue 3 , November 1976 , pp. 457 - 469
Copyright
Copyright © The Nutrition Society 1976

References

ARC/MRC Committee (1974). Food and Nutrition Research. Report of the ARC/MRC Committee, p. 34. London: H.M. Stationery Office.Google Scholar
Atkinson, T., Fowler, V. R., Garton, G. A. & Lough, A. K. (1972). Analyst, Lond. 97, 562.Google Scholar
Bray, G. A., York, D. A. & Swerloff, R. S. (1973). Metabolism 22, 435.Google Scholar
Brobeck, J. R. (1948). Yale J. Biol. Med. 20, 545.Google Scholar
Chesters, J. K. (1975). Proc. Nutr. Soc. 34, 103A.Google Scholar
Davidson, J., Mathieson, J. & Boyne, A. W. (1970). Analyst, Lond. 95, 181.Google Scholar
Harper, A. E., Benevenga, N. J. & Wohlhueter, R. W. (1970). Physiol. Rev. 50, 428.Google Scholar
Hoebel, B. G. & Teitelbaum, P. (1966). J. comp. Physiol. Psychol. 61, 189.CrossRefGoogle Scholar
Kennedy, G. C. (1953). Proc. R. Soc. B 140, 578.Google Scholar
McCance, R. A. & Widdowson, E. M. (1974). Proc. R. Soc. B 185, 1.Google Scholar
Mayer, J. (1955). Ann. N.Y. Acad. Sci. 63, 15.CrossRefGoogle Scholar
Meyer, J. H. (1958). Am. J. Physiol. 193, 488.Google Scholar
Meyer, J. H. & Hargus, W. A. (1959). Am. J. Physiol. 197, 1350.CrossRefGoogle Scholar
Pullar, J. D. & Webster, A. J. F. (1974). Br. J. Nutr. 31, 377.CrossRefGoogle Scholar
Radcliffe, J. D., Webster, A. J. F., Dewey, P. J. S. & Atkinson, T. (1975). Proc. Nutr. Soc. 34, 53A.Google Scholar
Zucker, L. M. (1975). Proc. Soc. exp. Biol. Med. 148, 498.Google Scholar
Zucker, L. M. & Zucker, T. R. (1961). J. Hered. 52, 275.Google Scholar