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Resistance to ketosis during prolonged fasting by rats fed on a diet containing undecanoic acid, an odd-carbon-number fatty acid

Published online by Cambridge University Press:  25 March 2008

F. X. Pi-Sunyer
F. X. Pi-Sunyer
Affiliation:
Department of Medicine and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, St Luke's Hospital Center, New York, NY 10025, USA
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Abstract

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1. Sixty-four male rats were fed on a nutritionally complete diet containing 30% of the dietary energy as fat. For thirty-two rats (control) the fat source was maize oil; for the remaining thirty-two rats (experimental) the fat source was triundecanoin–maize oil (7:3, w/w).

2. After 6 weeks, groups of control and experimental rats were fasted and killed on days 0, 1, 2 and 4 of the fasting period. In the experimental group, adipose-tissue fatty acids contained, on average, 246 mmol undecanoic acid/mol total fatty acids. In contrast, the adipose tissue of the control group did not contain odd-carbon-number fatty acids.

3. Plasma glucose levels were significantly higher for all fasted experimental groups and blood ketone levels were significantly lower for these groups.

4. Thus, during prolonged starvation, animals which accumulated odd-C-number fatty acids resisted the development of ketosis. It appeared that odd-C-number fatty acids mobilized from fat depots during fasting may provide their terminal three-C residues for gluconeogenesis rather than for acetyl-CoA production, thereby allowing for better maintenance of blood glucose and insulin levels than in control animals.

5. It is concluded that the lower acetyl-CoA production and higher blood insulin levels reduce ketogenesis.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 35 , Issue 1 , January 1976 , pp. 41 - 46
Copyright
Copyright © The Nutrition Society 1976

References

Butts, J. S., Blunden, H., Goodwin, W. & Deuel, H. J. Jr (1937). J. biol. Chem. 117, 131.CrossRefGoogle Scholar
Cahill, G. F. Jr, Aoki, T. T. & Ruderman, N. B. (1973). Trans. Am. clin. clim. Ass. 84, 184.Google Scholar
Cannata, J. J. B., Focesi, A. Jr, Mazumder, R., Warner, R. C. & Ochoa, S. (1965). J. biol. Chem. 240, 3249.CrossRefGoogle Scholar
Cheldelin, V. H. & Beinert, H. (1952). Biochim. biophys. Acta 9, 661.Google Scholar
Chernick, S. S. & Scow, R. O. (1959). Am. J. Physiol. 196, 125.CrossRefGoogle Scholar
Geuel, H. J. Jr, Butts, J. S., Hallman, L. F. & Cutler, C. H. (1935). J. biol. Chem. 112, 15.Google Scholar
Deuel, H. J. Jr, Hallman, L. F., Butts, J. S. & Murray, S. (1936). J. biol. Chem. 116, 621.CrossRefGoogle Scholar
Foster, D. W. (1967). J. clin. Invest. 46, 1283.Google Scholar
Hershey, J. M. & Orr, M. D. (1928). Trans. R. Soc. Can. Sect. 5, 22, 151.Google Scholar
Hoffman, W. S. (1937). J. biol. Chem. 120, 51.CrossRefGoogle Scholar
Jowett, M. & Quastel, J. H. (1935). Biochem. J. 29, 2159.Google Scholar
Kim, S. & Pi-Sunyer, F. X. (1974). Diabetes 23, 605.Google Scholar
Mazumder, R., Sasakawa, T. & Ochoa, S. (1963). J. biol. Chem. 238, 50.CrossRefGoogle Scholar
Parilla, R., Toews, C. S. & Cahill, G. F. Jr (1971). Proc. 53rd a. Meet. Endocr. Soc. p. A57.Google Scholar
Pi-Sunyer, F. X. (1971). Diabetes 20, 200.CrossRefGoogle Scholar
Shin, M. S. (1969). Nutrition and metabolic studies of a medium chain odd-numbered triglyceride PhD Thesis, Columbia University, New York.Google Scholar
Siegel, I. & Lorber, Y. ( 1951). J. biol. Chem. 189, 571.Google Scholar
Van Itallie, T. B. & Khachadurian, A. K. (1969). Science, N. Y. 165, 811.CrossRefGoogle Scholar
Williamson, D. H., Mellanby, J. & Krebs, H. A. (1962). Biochem. J. 82, 90.CrossRefGoogle Scholar
Witter, R. F., Cottone, M. A. & Stotz, E. (1954). J. biol. Chem. 207, 671.Google Scholar
Wooley, J. G. & Sebrell, W. H. (1945). J. Nutr. 29, 191.Google Scholar
Young, D. A. B. & Renold, A. E. (1966). Clinica chim. Acta 13, 791.CrossRefGoogle Scholar