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Superoxide dismutase (EC 1.15.1.1), manganese and the effect of ethanol in adult and foetal rats

Published online by Cambridge University Press:  09 March 2007

I. E. Dreosti ,
Susan J. Manuel  and
R. A. Buckley
I. E. Dreosti
Affiliation:
CSIRO Division of Human Nutrition, Adelaide, South Australia 5000, Australia
Susan J. Manuel
Affiliation:
CSIRO Division of Human Nutrition, Adelaide, South Australia 5000, Australia
R. A. Buckley
Affiliation:
CSIRO Division of Human Nutrition, Adelaide, South Australia 5000, Australia
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Abstract

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1. The activity of manganese-superoxide dismutase (EC 1.15.1; SOD) was increased in the livers and kidneys of adult rats after exposure to aqueous ethanol (200 ml/l) for 32 weeks.

2. The concentration of Mn in the livers and kidneys was significantly higher after 24 weeks, and by 32 weeks liver copper and zinc levels were lower.

3. The activity of foetal (day 19) liver superoxide dismutase was appreciably higher in offspring from dams receiving ethanol during pregnancy. Quantitatively the response appeared to be almost entirely due to the Mn-SOD form of the enzyme.

4. Maternal alcoholism during pregnancy had no effect on the levels of Cu, Mn or Zn in foetal (day 19) livers.

Type
Papers of direct reference to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 48 , Issue 2 , September 1982 , pp. 205 - 210
Copyright
Copyright © The Nutrition Society 1982

References

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