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Thyroid function in rats with iodine deficiency is not further impaired by concurrent, marginal zinc deficiency

Published online by Cambridge University Press:  09 March 2007

John G. G. Smit ,
Daan Van Der Heide ,
Gerrit Van Tintelen  and
Anton C. Beynen
John G. G. Smit
Affiliation:
Department of Human and Animal Physiology, Agricultural University, Wageningen, The Netherlands Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands
Daan Van Der Heide
Affiliation:
Department of Human and Animal Physiology, Agricultural University, Wageningen, The Netherlands
Gerrit Van Tintelen
Affiliation:
Laboratory Animals Centre, Agricultural University, Wageningen, The Netherlands
Anton C. Beynen
Affiliation:
Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands Department of Large Animal Medicine and Nutrition, State University, Utrecht, The Netherlands Department of Laboratory Animal Science, State University, Utrecht, The Netherlands
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Abstract

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The hypothesis tested was that Zn deficiency aggravates impaired thyroid function as induced by I deficiency. In two separate experiments male rats were fed on diets either deficient in Zn or in I, or deficient in both. An identical, restricted amount of food was given to each rat so that body-weight gain of the experimental groups was comparable. Zn deficiency was evidenced by reduced tibial Zn concentrations. I deficiency was evidenced by goitre, reduced urinary I excretion, reduced plasma thyroxine concentrations and reduced absolute amounts and concentrations of thyroxine in the thyroid. Zn deficiency had no effect on the raised thyroid weight as induced by I deficiency. Zn restriction from 184 μmol Zn/kg diet to 31 μmol Zn/kg diet, hut not to 92 μmol Zn/kg diet, significantly lowered plasma thyroxine concentration. There were no interrelated effects of Zn and I deficiencies on thyroid hormone levels. These results indicate that marginal Zn deficiency does not influence thyroid hormone metabolism in I deficiency.

Keywords

RatsZincIodineThyroid
Type
Interactions between Micronutrient Status
Information
British Journal of Nutrition , Volume 70 , Issue 2 , September 1993 , pp. 585 - 592
Copyright
Copyright © The Nutrition Society 1993

References

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