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α-Tocopherol supplements and high-density-lipoprotein–cholesterol levels

Published online by Cambridge University Press:  09 March 2007

John H. Kalbfleisch ,
Joseph J. Barboriak ,
Barbara A. Else ,
C. Vincent Hughes  and
Felix E. Tristani
John H. Kalbfleisch
Affiliation:
Research Service1, Veterans Administration Medical Center, Milwaukee, Wisconsin 53193, USA Departments of Anesthesiology3, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Joseph J. Barboriak
Affiliation:
Research Service1, Veterans Administration Medical Center, Milwaukee, Wisconsin 53193, USA Pharmacology4, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Barbara A. Else
Affiliation:
Cardiopulmonary Rehabilitation Center2, Veterans Administration Medical Center, Milwaukee, Wisconsin 53193, USA
C. Vincent Hughes
Affiliation:
Cardiopulmonary Rehabilitation Center2, Veterans Administration Medical Center, Milwaukee, Wisconsin 53193, USA Medicine5, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Felix E. Tristani
Affiliation:
Cardiopulmonary Rehabilitation Center2, Veterans Administration Medical Center, Milwaukee, Wisconsin 53193, USA Medicine5, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
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Abstract

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1. In a randomized, double-blind 6-month study, α-tocopherol (728 mg) or placebo were administered daily to seventy-eight volunteers (forty-nine men, twenty-nine women) to investigate the possible enhancing effect of vitamin E on plasma high-density-lipoprotein-cholesterol (HDL-C) levels. In addition, the available reported values from short-term (4–6 weeks) studies, as well as the 4-week results from the present study, were combined and analysed for factors which may modify the effect of α-tocopherol on HDL-C.

2. No consistent effect of α-tocopherol on plasma HDL-C levels was observed either in the combined 4-week values or in the 6-month study. Further analysis of the combined short-term values and 6-month values indicated that, in subjects with low initial HDL-C levels, treatment with α-tocopherol or placebo did not produce significantly different HDL-C changes.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 55 , Issue 1 , January 1986 , pp. 71 - 77
Copyright
Copyright © The Nutrition Society 1986

References

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