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The rôle of the gastrointestinal tract in the control of voluntary food intake

Published online by Cambridge University Press:  27 February 2018

D. V. Rayner  and
P. C. Gregory
D. V. Rayner
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
P. C. Gregory
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
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Abstract

The short-term regulation of intake is thought to be achieved at least in part by signals from the gastrointestinal tract. Infusions of glucose, protein hydrolysate or emulsified fat into the stomach, and of glucose or protein hydrolysate into the duodenum, jejunum or ileum caused pigs to reduce their intake to compensate approximately for the energy infused, probably through the regulation of gastric emptying. Protein or protein hydrolysate infusions also caused a long-term inhibition of intake for 30 h by up to three times the energy infused. During feeding gastric emptying occurred at a constant rate of calories, the rate increasing linearly with body weight; duodenal infusion of glucose slowed gastric emptying to compensate for the infused energy and satiety occurred at a reduced food intake but at the same stomach volume. Duodenal infusion of emulsified fat caused a greater than caloric inhibition of intake, which was blocked by the cholecystokinin (CCK) antagonist L-364,718 and appeared to be mediated through a mono-glyceride-induced CCK release. Emulsified fat infused into the duodenum slowed gastric emptying by more than the energy infused and the gastric volume at satiety was decreased suggesting that the effects of fats on intake are possibly independent of gastric emptying. Since L-364,718 did not increase intake on a normal diet (186 g protein, 20 g fat per kg), CCK may only contribute to satiety in pigs eating high-fat diets.

Type
Research Article
Information
BSAP Occasional Publication , Volume 13: The Voluntary Food Intake of Pigs , 1989 , pp. 27 - 39
Copyright
Copyright © British Society of Animal Production 1989

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