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Anomalous Gene Expression in Alzheimer Disease: Cause or Effect

Published online by Cambridge University Press:  18 September 2015

D.R.C. McLachlan ,
W.J. Lukiw ,
C. Mizzen ,
M.E. Percy ,
M.J. Somerville ,
M.K. Sutherland  and
L. Wong
D.R.C. McLachlan*
Affiliation:
Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada M5S 2C2
W.J. Lukiw
Affiliation:
Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada M5S 2C2
C. Mizzen
Affiliation:
Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada M5S 2C2
M.E. Percy
Affiliation:
Department of Genetics, Surrey Place Centre, University of Toronto, Toronto, Canada M5S 2C2
M.J. Somerville
Affiliation:
Department of Genetics, Surrey Place Centre, University of Toronto, Toronto, Canada M5S 2C2
M.K. Sutherland
Affiliation:
Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada M5S 2C2
L. Wong
Affiliation:
Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada M5S 2C2
*
Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada M5S 1A8
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Abstract:

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Altered chromatin conformation and increased amounts of aluminum have been observed in the brains of patients with Alzheimer disease. These factors have been shown to affect gene regulation. In this report, we describe how these changes may selectively alter the pool size of the human light chain neurofilament gene and play a fundamental role in the expression of this disease.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue S3 , August 1991 , pp. 414 - 418
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

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