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Calcium Antagonists, Cerebral Ischemia and Vasospasm

Published online by Cambridge University Press:  18 September 2015

Bryce Weir
Bryce Weir*
Affiliation:
Division of Neurosurgery, University of Alberta
*
Division of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada T6G 2G3
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Abstract:

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The past fifteen years has seen the classification of diverse substances into a group known as calcium antagonists (CAs). They have a common ability to reduce the transmembrane transport of extracellular calcium ions (CAe2+). This flow of calcium into vascular smooth muscle is ultimately associated with the development of tension and vasoconstriction. Some CAs appear to have a predilection for cerebral as opposed to systemic arteries and so may function as specific cerebral arterial vasodilators. It has been proposed that they might be useful in certain types of cerebral ischemia such as that due to arterial occlusion or prolonged vasoconstriction. Animal experiments and initial clinical trials give grounds for cautious optimism that CAs may become as useful in neurology as they have recently become in cardiology.

Type
Special Features
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue 2 , May 1984 , pp. 239 - 246
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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