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Cerebral Hemodynamics in Migraine

Published online by Cambridge University Press:  18 September 2015

V. C. Hachinski ,
J. Olesen ,
J. W. Norris ,
B. Larsen ,
E. Enevoldsen  and
N. A. Lassen
V. C. Hachinski*
Affiliation:
MachLachlan Stroke Unit, Sunnybrook Medical Centre, Toronto, Canada
J. Olesen
Affiliation:
Department of Neurology, Rigshospitalet, Copenhagen, Denmark
J. W. Norris
Affiliation:
MachLachlan Stroke Unit, Sunnybrook Medical Centre, Toronto, Canada
B. Larsen
Affiliation:
Department of Clinical Physiology, Bispebjerk Hospital, Copenhagen, Denmark
E. Enevoldsen
Affiliation:
Department of Neurology, Arhus Communehospital, Arhus, Denmark
N. A. Lassen
Affiliation:
Department of Clinical Physiology, Bispebjerk Hospital, Copenhagen, Denmark
*
Sunnybrook Medical Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
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Summary:

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Clinical and angiographic findings in migraine are briefly reviewed in relation to cerebral hemodynamic changes shown by regional cerebral blood flow (rCBF) studies. Three cases of migraine studied by the intracarotid xenon 133 method during attacks are reported.

In classic migraine, with typical prodromal symptoms, a decrease in cerebral blood flow has been demonstrated during the aura. Occasionally, this flow decrease persists during the headache phase. In common migraine, where such prodr.omata are not seen, a flow decrease has not been demonstrated.

During the headache phase of both types of migraine, rCBF has usually been found to be normal or in the high range of normal values. The high values may represent postischemic hyperemia, but are probably more frequently secondary to arousal caused by pain.

Thus, during the headache phase rCBF may be subnormal, normal or high. These findings do not exclude the possibility of distension of the larger intracranial arteries during migraine headache, but the angiographic evidence, however limited, does not support this speculation.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 4 , Issue 4 , November 1977 , pp. 245 - 249
Copyright
Copyright © Canadian Neurological Sciences Federation 1977

References

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