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The Cerebral Ischemic Penumbra

Published online by Cambridge University Press:  18 September 2015

Antoine M. Hakim
Antoine M. Hakim*
Affiliation:
The Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
*
Brain Imaging Centre, Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
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Abstract

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Type
Editorial Review
Information
Canadian Journal of Neurological Sciences , Volume 14 , Issue 4 , November 1987 , pp. 557 - 559
Copyright
Copyright © Canadian Neurological Sciences Federation 1987

References

1.Symon, L. The relationship between CBF, evoked potentials and the clinical features in cerebral ischemia. Acta Neurol Scand 1980; Suppl 78, 62: 175–190.Google Scholar
2.Astrup, J. Energy-requiring cell functions in the ischemic brain. J Neurosurg 1982; 56: 482–297.CrossRefGoogle ScholarPubMed
3.Symon, L, Lassen, NA, Astrup, J. Thresholds of ischemia in brain cortex. Adv Exp Med Biol 1977; 94: 775–82.CrossRefGoogle ScholarPubMed
4.Astrup, J, Siesjö, , Symon, L. Thresholds in cerebral ischemia — The ischemie penumbra. Stroke 1981; 12: 723–725.CrossRefGoogle Scholar
5.Heiss, W-D, Hayakawa, T, Walz, AG. Cortical neuronal function during ischemia. Arch Neurol 1976; 33: 813–820.CrossRefGoogle ScholarPubMed
6.Morawetz, RB, DeGirolami, U, Ojemann, RG, et al. Cerebral blood flow determined by hydrogen clearance during middle cerebral artery occlusion in unanesthetized monkeys. Stroke 1978; 9: 143–149.CrossRefGoogle ScholarPubMed
7.Jones, TH, Morawetz, RB, Crowell, RM, et al. Thresholds of focal cerebral ischemia in awake monkeys. J Neurosurg 1981; 54: 773–782.CrossRefGoogle ScholarPubMed
8.Nedergaard, M, Gjedde, A, Diemer, NH. Focal ischemia of the rat brain: Autoradiographic determination of cerebral glucose utilization, glucose content, and blood flow. J Cereb Blood Flow and Metab 1986; 6: 414–424.CrossRefGoogle ScholarPubMed
9.Astrup, J, Symon, L, Branston, NM, et al. Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia. Stroke 1977; 8: 51–57.CrossRefGoogle Scholar
10.Peters, T. Calcium in physiological and pathological cell function. Eur Neurol 1986; 25 (Suppl 1): 27–44.CrossRefGoogle ScholarPubMed
11.Marcoux, FW, Morawetz, RB, Crowell, RM, et al. Differential regional vulnerability in transient focal cerebral ischemia. Stroke 1982; 13: 339–346.CrossRefGoogle ScholarPubMed
12.Rosner, G, Heiss, W-D. Survival of cortical neurons as a function of residual flow and duration of ischemia. J Cereb Blood Flow and Metab 1983; 3 (Suppl 1): S393–394.Google Scholar
13.Carter, LP, Yamagata, S, Erspamer, R. Time limits of reversible cortical ischemia. Neurosurgery 1983; 12: 620–623.CrossRefGoogle ScholarPubMed
14.Powers, WJ, Grubb, RL, Raichle, ME. Physiological responses to focal cerebral ischemia in humans. Ann Neurol 1984; 16: 546–552.CrossRefGoogle ScholarPubMed
15.Cremer, JE, Cunningham, VJ, Seville, MP. Relationships between extraction and metabolism of glucose, blood flow, and tissue blood volume in regions of rat brain. J Cereb Blood Flow and Metab 1983; 3: 291–302.CrossRefGoogle ScholarPubMed
16.Nedergaard, M, Vorstrup, S, Astrup, J. Cell density in the border zone around old small human brain infarcts. Stroke 1986; 17: 1129–1137.CrossRefGoogle ScholarPubMed
17.Miles, G, Auer, LM, Ebhardt, G, et al. Flow and neuronal density of tissue surrounding chronic infarction. Stroke 1983; 14: 22–27.Google Scholar
18.Hakim, AM, Pokrupa, RP, Villaneuva, J, et al. The effect of spontaneous reperfusion on metabolic function in early human cerebral infarcts. Ann Neurol 1987; 21: 279–289.CrossRefGoogle ScholarPubMed
19.Wagner, JA, Reynolds, IJ, Weisman, HF, et al. Calcium antagonist receptors in cardiomyopathic hamster: Selective increases in heart, muscle, brain. Science 1986; 232: 515–518.CrossRefGoogle ScholarPubMed
20.Hochachka, PW. Defense strategies against hypoxia and hypothermia. Science 1986; 231: 234–241.CrossRefGoogle ScholarPubMed
21.The EC/IC Bypass Study Group. Failure of extracranial-intracranial arterial bypass to reduce the risk of ischemic stroke. N Engl J Med 1985; 313: 1191–1200.CrossRefGoogle Scholar
22.Hsu, CY, Faught, RE Jr, Furlan, AJ, et al. Intravenous prostacyclin in acute nonhemorrhagic stroke: A placebo-controlled double-blind trial. Stroke 1987; 18(2): 352–358.CrossRefGoogle ScholarPubMed
23.Leblanc, R, Tyler, J, Mohr, G, et al. Hemodynamic and metabolic effects of cerebral revascularization. J Neurosurgery 1987; 66:529–535.CrossRefGoogle ScholarPubMed
24.Pokrupa, R, Hakim, AM, Villaneuva, J, et al. Clinical study of prostacyclin infusion after acute ischemic stroke. Can J Neurol Sci 1986; 13: 188.Google Scholar