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Failed Compensatory Dendritic Growth as a Pathophysiological Process in Alzheimer's Disease

Published online by Cambridge University Press:  18 September 2015

Dorothy G. Flood  and
Paul D. Coleman
Dorothy G. Flood*
Affiliation:
Department of Neurology and the Department of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, New York
Paul D. Coleman
Affiliation:
Department of Neurology and the Department of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, New York
*
Department of Neurology, Box 673, University of Rochester Medical Center, Rochester, New York U.S.A. 14642
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Abstract:

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In normal human aging the remaining neurons of two areas of the hippocampal region have been found to compensate for age-related neuronal loss by proliferating new dendrites. In Alzheimer's disease (AD) the layer II pyramidal neurons of the parahippocampal gyrus fail to show this compensatory response, in spite of a probable, exaggerated disease-related loss of neurons. In AD the dentate gyrus granule cells of the hippocampus also show a reduced amount of the compensatory response. This failure of the AD brain to show the normal compensatory plastic response, seen in normal aging as dendritic growth, may be viewed as one of the pathophysiological processes of the disease.

Type
Cellular Clues to Pathogenesis
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 475 - 479
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

References

1.Brody, H. Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex. J Comp Neurol 1955; 102:511–556.CrossRefGoogle Scholar
2.Shefer, VF. Absolute number of neurons and thickness of the cerebral cortex during aging, senile and vascular dementia, and Pick’s and Alzheimer’s diseases. Neurosci Behav Physiol 1973; 6: 319–324.CrossRefGoogle ScholarPubMed
3.Henderson, G, Tomlinson, BE, Gibson, PH. Cell counts in human cerebral cortex in normal adults throughout life using an image analysing computer. J Neurol Sci 1980; 46: 113–136.CrossRefGoogle ScholarPubMed
4.Anderson, JM, Hubbard, BM, Coghill, GR, et al. The effect of advanced old age on the neurone content of the cerebral cortex. Observations with an automatic image analyser point counting method. J. Neurol Sci 1983; 58: 233–244.CrossRefGoogle ScholarPubMed
5.Mann, DMA, Yates, PO, Marcyniuk, B. Some morphometric observations on the cerebral cortex and hippocampus in presenile Alzheimer’s disease, senile dementia of Alzheimer type and Down’s syndrome in middle age. J Neurol Sci 1985; 69: 139–159.CrossRefGoogle ScholarPubMed
6.Ball, MJ. Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study. Acta Neuropathol (Berl) 1977; 37: 111–118.CrossRefGoogle ScholarPubMed
7.Mouritzen Dam, A. The density of neurons in the human hippo campus. Neuropathol Appl Neurobiol 1979; 5: 249–264.Google Scholar
8.Hinds, JW, McNelly, NA. Aging of the rat olfactory bulb: Growth and atrophy of constituent layers and changes in size and number of mitral cells. J Comp Neurol 1977; 171: 345–368.CrossRefGoogle Scholar
9.Coleman, PD, Flood, DG. Dendritic proliferation in the aging brain as a compensatory repair mechanism. Prog Brain Res 1986; 70: 227–237.CrossRefGoogle ScholarPubMed
10.Coleman, PD, Buell, SJ. Regulation of dendritic extent in developing and aging brain. In: Cotman, CW, ed. Synaptic Plasticity. New York: The Guilford Press, 1985: 311–333.Google Scholar
11.Buell, SJ, Coleman, PD. Dendritic growth in the aged human brain and failure of growth in senile dementia. Science 1979; 206: 854–856.CrossRefGoogle ScholarPubMed
12.Buell, SJ, Coleman, PD. Quantitative evidence for selective dendritic growth in normal human aging but not in senile dementia. Brain Res 1981; 214: 23–41.CrossRefGoogle ScholarPubMed
13.Cupp, CJ, Uemura, E. Age-related changes in prefrontal cortex of Macaca mulatto: Quantitative analysis of dendritic branching patterns. Exp Neurol 1980; 69: 143–163.CrossRefGoogle Scholar
14.Uemura, E. Age-related changes in the subiculum of Macaca mulatta: Dendritic branching pattern. Exp Neurol 1985; 87: 412–427.CrossRefGoogle ScholarPubMed
15.Buell, SJ, Coleman, PD. Individual differences in dendritic growth in human aging and senile dementia. In: Stein, D, ed. The Psycho-biology of Aging: Problems and Perspectives. Amsterdam: Elsevier, 1980: 283–296.Google Scholar
16.Flood, DG, Buell, SJ, Horwitz, GJ, et al. Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia. Brain Res 1986 (in press).Google Scholar
17.Van der Loos, H. Une combinaison de deux vieilles méthodes histologiques pour le système nerveux central. Monatsschr Psychiatr Neurol 1956; 132: 330–334.CrossRefGoogle Scholar
18.Bodian, D. A new method for staining nerve fibers and nerve endings in mounted paraffin sections. Anat Rec 1936; 65: 89–97.CrossRefGoogle Scholar
19.Lindsay, RD, Scheibel, AB. Quantitative anaylsis of dendritic branching pattern of granular cells from human dentate gyrus. Exp Neurol 1976; 52: 295–310.CrossRefGoogle Scholar
20.Connor, JR, Diamond, MC, Johnson, RE. Occipital cortical morphology of the rat: Alterations with age and environment. Exp Neurol 1980; 68: 158–170.CrossRefGoogle ScholarPubMed
21.Connor, JR, Beban, SE, Hopper, PA, et al. A Golgi study of the superficial pyramidal cells in the somatosensory cortex of socially reared old adult rats. Exp Neurol 1982; 76: 35–45.CrossRefGoogle ScholarPubMed
22.Hinds, JW, McNelly, N.A. Aging in the rat olfactory system: Correlation of changes in the olfactory epithelium and olfactory bulb. J Comp Neurol 1981; 203: 441–453.CrossRefGoogle ScholarPubMed
23.Flood, DG, Coleman, PD. Age-related changes in dendritic extent of neurons in supraoptic nucleus of F344 rats. Soc Neurosci Abstr 1983; 9: 930.Google Scholar
24.Rogers, J, Zornetzer, SF, Bloom, FE, et al. Senescent microstructural changes in rat cerebellum. Brain Res 1984; 292: 23–32.CrossRefGoogle ScholarPubMed
25.Pentney, RJ. Quantitative analysis of dendritic networks of Purkinje neurons during aging. Neurobiol Aging 1986 (in press).CrossRefGoogle ScholarPubMed
26.Pysh, JJ, Benson, MD. Purkinje cell dendrites in aged rats: A morphometric Golgi analysis. Soc Neurosci Abstr 1980; 6: 281.Google Scholar
27.Coleman, PD, Buell, SJ. Dendritic extent of layer II pyramids in entorhinal cortex of aging F344 rat. Soc Neurosci Abstr 1983; 9: 930.Google Scholar
28.Geddes, JW, Monaghan, DT, Cotman, CW, et al. Plasticity of hippocampal circuitry in Alzheimer’s disease. Science 1985; 230: 1179–1181.CrossRefGoogle ScholarPubMed
29.Hyman, BT, Van Hoesen, GW, Damasio, AR, et al. Alzheimer’s disease: Cell-specific pathology isolates the hippocampal formation. Science 1984; 225: 1168–1170.CrossRefGoogle ScholarPubMed
30.Lorente de No, R. Studies on the structure of the cerebral cortex. II. Continuation of the study of the ammonic system. J Psychol Neurol (Leipzig) 1934; 46: 113–177.Google Scholar
31.Van Hoesen, GW, Pandya, DN. Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. III. Efferent connections. Brain Res 1975; 95: 39–59.CrossRefGoogle ScholarPubMed
32.Hirano, A, Zimmerman, HM. Alzheimer’s neurofibrillary changes. A topographic study. Arch Neurol 1962; 7: 227–242.CrossRefGoogle ScholarPubMed
33.Schade, JP, Baxter, CF. Changes during growth in the volume and surface area of cortical neurons in the rabbit. Exp Neurol 1960; 2: 158–178.CrossRefGoogle ScholarPubMed
34.Flood, DG, Buell, SJ, DeFiore, CH, et al. Age-related dendritic growth in dentate gyrus of human brain is followed by regression in the Oldest old’. Brain Res 1985; 345: 366–368.CrossRefGoogle ScholarPubMed
35.Whitehouse, PJ, Price, DL, Struble, RG, et al. Alzheimer’s disease and senile dementia: Loss of neurons in the basal forebrain. Science 1982; 215: 1237–1239.CrossRefGoogle ScholarPubMed
36.Candy, JM, Perry, RH, Perry, EK, et al. Pathological changes in the nucleus of Meynert in Alzheimer’s and Parkinson’s diseases. J Neurol Sci 1983; 54: 277–289.CrossRefGoogle Scholar
37.Tagliavini, F, Pilleri, G. Basal nucleus of Meynert. A neuropathological study in Alzheimer's disease, simple senile dementia, Pick’s disease and Huntington’s chorea. J Neurol Sci 1983; 62: 243–260.CrossRefGoogle ScholarPubMed
38.Wilcock, GK, Esiri, MM, Bowen, DM, et al. The nucleus basalis in Alzheimer’s disease: Cell counts and cortical biochemistry. Neuropathol Appl Neurobiol 1983; 9: 175–179.CrossRefGoogle ScholarPubMed
39.Mann, DMA, Yates, PO, Marcyniuk, B. Changes in nerve cells of the nucleus basalis of Meynert in Alzheimer’s disease and their relationship to ageing and to the accumulation of lipofuscin pigment. Mech Ageing Dev 1984; 25: 189–204.CrossRefGoogle Scholar
40.McGeer, PL, McGeer, EG, Suzuki, J, et al. Aging, Alzheimer’s disease, and the cholinergic system of the basal forebrain. Neurology 1984; 34: 741–745.CrossRefGoogle ScholarPubMed
41.Arendt, T, Bigl, V, Tennstedt, A, et al. Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in Alzheimer’s disease. Neuroscience 1985; 14: 1–14.CrossRefGoogle ScholarPubMed