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Future Treatment of Parkinson’s Disease

Published online by Cambridge University Press:  18 September 2015

Joseph King Ching Tsui
Joseph King Ching Tsui*
Affiliation:
Division of Neurology, Department of Medicine, University of British Columbia, Vancouver
*
Division of Neurology, Department of Medicine, University Hospital – UBC Site, 2211 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 1W5
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Abstract:

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New methods of drug delivery and slowing down the progression of Parkinson’s disease (PD) are the major goals of research. More steady drug levels in the blood are possible by means of controlled-release preparations of levodopa and long-acting dopamine agonists, as well as transcutaneous duodenal tubes and pumps for controlled subcutaneous infusion. Patches containing dopamine agonists absorbed through the skin may be developed. The role of D1 agonists as compared with D2 agonists remains to be elucidated. Agonists on autoreceptors of dopaminergic neurons may potentially reduce excessive stimulation of the intact neurons and this may slow down the rate of neuronal death in PD. Monoamine oxidase-B inhibitors may have a potentially protective action on neurons. Investigations are being carried out to evaluate this claim. Catechol-o-methyl-transferase inhibitors may be helpful in theory. There is also recent interest in inhibitors of excitatory amino acids, which may contribute to neuronal loss in PD.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue S1: 3rd Canadian Conference on Neurodegenerative Diseases , February 1992 , pp. 160 - 162
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

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