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Kindling: Secondary Epileptogenesis, Sleep and Catecholamines

Published online by Cambridge University Press:  18 September 2015

Mitsumoto Sato  and
Toyoji Nakashima
Mitsumoto Sato*
Affiliation:
Department of Neuropsychiatry, School of Medicine, Okayama University
Toyoji Nakashima
Affiliation:
Department of Neuropsychiatry, School of Medicine, Okayama University
*
Department of Neuropsychiatry, School of Medicine, Okayama University Hospital, Okayama City, Japan
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Seizure development and transference phenomenon were investigated in hippocampal and amygdaloid kindled cats. The behavioral and electrographic findings during the kindling procedures showed that motor seizure development in hippocampal seizures occurred with the emergence of independent discharging in the amygdala, globus pallidus and contralateral hippocampus. Furthermore, secondary site convulsions developed upon the first stimulation of these structures in the hippocampal group but only after over a month of hippocampal stimulation in the amygdaloid group. It was, therefore, concluded that role of the amygdala and globus pallidus in hippocampal seizure development was more essential than that of hippocampal stimulation in amygdaloid seizure development. The common findings between the hippocampal and amygdaloid kindled animals were the systematic progression to seizures, the all-or-nothing nature of the electrical response and the relative permanency of the seizure susceptibility. Seizure susceptibility increased during slow wave sleep and decreased during REM sleep. These latter findings were examined with preliminary data of brain bioassays of catecholamines.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 4 , November 1975 , pp. 439 - 446
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

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