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Large Unresponsive Zones Appear in Cat Somatosensory Cortex Immediately After Ulnar Nerve Cut

Published online by Cambridge University Press:  18 September 2015

Cheng-Xiang Li ,
Robert S. Waters ,
Akinniran Oladehin ,
Eldridge F. Johnson ,
Carl A. McCandlish  and
Robert W. Dykes
Cheng-Xiang Li*
Affiliation:
Department of Anatomy and Neurobiology,
Robert S. Waters
Affiliation:
Department of Anatomy and Neurobiology,
Akinniran Oladehin
Affiliation:
Physical and Occupational Therapy, University of Tennessee, Memphis, College of Medicine, Memphis
Eldridge F. Johnson
Affiliation:
Department of Anatomy and Neurobiology,
Carl A. McCandlish
Affiliation:
Department of Anatomy and Neurobiology,
Robert W. Dykes
Affiliation:
University of Tennessee. Memphis, College of Medicine, Memphis; and the Department of Physiology, University of Montreal, Montreal
*
Department of Anatomy and Neurobiology, University of Tennessee, Memphis, 875 Monroe Avenue, Memphis, Tennessee, USA 38163
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Abstract:

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The organization of the primary somatosensory cortex innervated by the ulnar nerve was studied before and immediately after ulnar nerve transection in 11 cats electrophysiologically mapped under Nembutal or Ketamine anesthesia. The cortex was reexamined a second time beginning 42 hr after nerve transection in four cats anesthetized with Nembutal. One additional sham-operated control was also mapped. The region of cortex formerly served by the ulnar nerve remained largely unresponsive to somatic stimulation independent of the type of anesthetic used during recording. Nonetheless, animals anesthetized with Ketamine had more new responsive sites in deafferented cortex following nerve cut than cats anesthetized with Nembutal. New responses, when observed, were evoked by stimulation of a region of skin adjacent to the region served by the ulnar nerve. These findings suggest that the immediate response to deafferentation of somatosensory cortex is a limited acquisition of novel responses restricted to a region immediately adjacent to cortex containing normal afferent input.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 21 , Issue 3 , August 1994 , pp. 233 - 247
Copyright
Copyright © Canadian Neurological Sciences Federation 1994

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