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Meta-Analysis of Aldehyde Dehydrogenase 2 Gene Polymorphism and Alzheimer's Disease in East Asians

Published online by Cambridge University Press:  02 December 2014

Pan-Pan Hao ,
Yu-Guo Chen ,
Jia-Li Wang ,
Xing Li Wang  and
Yun Zhang
Pan-Pan Hao
Affiliation:
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China
Yu-Guo Chen*
Affiliation:
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China
Jia-Li Wang
Affiliation:
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China
Xing Li Wang
Affiliation:
Division of Cardiothoracic Surgery, The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
Yun Zhang*
Affiliation:
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China
*
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, No. 107, Wen Hua Xi Road, Jinan 250012, China. Pan-Pan Hao and Jia-Li contributed to this work equally.
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, No. 107, Wen Hua Xi Road, Jinan 250012, China. Pan-Pan Hao and Jia-Li contributed to this work equally.
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Abstract

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Background:

The association of genetic polymorphism of mitochondrial aldehyde dehydrogenase 2 (ALDH2) and Alzheimer's disease (AD) has been controversial and has been investigated only in several small-sample studies. In the present study, we performed a meta-analysis to evaluate the cross-sectional association of ALDH2 variants and AD risk in East Asian populations.

Methods:

Trials were retrieved through MEDLINE, EMBASE, J-STAGE and the China National Knowledge Internet databases (from January 1, 1994 to November 1, 2010) without any restriction on language. Data were abstracted by a standardized protocol.

Results:

We found four studies of 821AD patients and 1380 healthy controls that qualified for the analysis. The variant ALDH2 genotype GA/AA was not associated with increased AD risk (odds ratio (OR) = 1.35; 95% confidence interval (CI) = 0.75-2.42; p = 0.32), even after stratification for the status of apolipoprotein E epsilon 4 allele. However, in the subgroup analyses, the association was significant for men (OR = 1.72; 95% CI = 1.10-2.67; p = 0.02).

Conclusions:

This study adds to the evidence that ALDH2 GA/AA genotype increases the risk of AD among East Asian men, although the effect size is moderate.

Résumé:

Résumé:Contexte:

L’association entre le polymorphisme du gene de l’aldehyde deshydrogenase 2 (ALDH2) et la maladie d’Alzheimer (MA) est controversee et elle a ete examinee seulement au cours d’etudes faites chez un petit nombre de sujets. Nous avons effectue une meta-analyse pour evaluer l’association transversale de variations dans le gene de l’ALDH2 et le risque de MA dans des populations de l’Asie de l‘Est.

Méthode:

Nous avons identifie les etudes dans MEDLINE, EMBASE, J-STAGE et dans les bases de donnees de China National Knowledge Internet, du 1er janvier 1994 au 1er novembre 2010, sans restriction quant a la langue de publication. Les donnees ont ete recueillies selon un protocole standardise.

Résultats:

Nous avons identifie 4 etudes portant sur un total de 821 patients atteints de MA et 1380 temoins en bonne sante, qui rencontraient les criteres etablis pour l’analyse. La variante genotypique GA/AA du gene de l’ALDH2 n’etait pas associee a un risque accru de MA(RC = 1,35; IC a 95% : 0,75 a 2,42; p = 0,32), meme apres ajustement pour la presence de l’allele epsilon 4 du gene de l’apolipoproteine E. Cependant, dans les analyses de sous-groupes, l’association etait significative chez les hommes (RC = 1,72 ; IC a 95% : 1,10 a 2,67; p = 0,02).

Conclusions:

Cette etude appuie la notion que le genotype GA/AA du gene de l’ALDH2 augmente le risque de MA chez les hommes de l’Asie de l‘Est, mais que cet effet est modere.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 38 , Issue 3 , May 2011 , pp. 500 - 506
Copyright
Copyright © The Canadian Journal of Neurological 2011

References

1 Blacker, D, Haines, JL, Rodes, L, et al. ApoE-4 and age at onset of Alzheimer’s disease: the NIMH genetics initiative. Neurology. 1997;48(1):139–47.Google Scholar
2 Hosoda, A, Inoue, T, Mao, CC, et al. Polymorphisms in the human apolipoprotein E receptor 2 gene in Japanese sporadic Alzheimer’s disease patients. Biosci Biotechnol Biochem. 2010: 74(3):677–9.Google Scholar
3 Ohta, S, Ohsawa, I. Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer’s disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification. J Alzheimer’s Dis. 2006;9(2):155–66.CrossRefGoogle ScholarPubMed
4 Tanzi, RE, Bertram, L. New frontiers in Alzheimer’s disease genetics. Neuron. 2001;32(2):181–4.Google Scholar
5 Picklo, MJ, Olson, SJ, Markesbery, WR, Montine, TJ. Expression and activities of aldo-keto oxidoreductases in Alzheimer disease. J Neuropathol Exp Neurol. 2001;60(7):686–95.Google Scholar
6 Chen, CH, Budas, GR, Churchill, EN, Disatnik, MH, Hurley, TD, Mochly-Rosen, D. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science. 2008;321(5895): 1493–5.Google Scholar
7 Li, Y, Zhang, D, Jin, W, et al. Mitochondrial aldehyde dehydrogenase- 2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin. J Clin Invest. 2006;116(2):506–11.Google Scholar
8 Michel, TM, Gsell, W, Kasbauer, L, et al. Increased activity of mitochondrial aldehyde dehydrogenase (ALDH) in the putamen of individuals with Alzheimer’s disease: a human postmortem study. J Alzheimers Dis. 2010;19(4):1295–301.Google Scholar
9 Wang, B, Wang, J, Zhou, S, et al. The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer’s disease in Chinese. J Neurol Sci. 2008;268(1-2):172–5.Google Scholar
10 Kamino, K, Nagasaka, K, Imagawa, M, et al. Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer’s disease in the Japanese population. Biochem Biophys Res Commun. 2000;273(1):192–6.CrossRefGoogle ScholarPubMed
11 Kim, JM, Stewart, R, Shin, IS, Jung, JS, Yoon, JS. Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer’s disease in an older Korean population. Neurobiol Aging. 2004;25(3):295–301.Google Scholar
12 Shin, IS, Stewart, R, Kim, JM, et al. Mitochondrial aldehyde dehydrogenase polymorphism is not associated with incidence of Alzheimer’s disease. Int J Geriatr Psychiatry. 2005;20(11): 1075–80.Google Scholar
13 Zhou, S, Huriletemuer, , Wang, J, et al. Absence of association on aldehyde dehydrogenase 2 (ALDH2) polymorphism with Mongolian Alzheimer patients. Neurosci Lett. 2010;468(3): 312–15.Google Scholar
14 Higgins, JP, Thompson, SG, Deeks, JJ, Altman, DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–60.Google Scholar
15 Cohn, LD, Becker, BJ. How meta-analysis increases statistical power. Psychol Methods. 2003;8(3):243–53.Google Scholar
16 Butterworth, RF. Pathophysiology of alcoholic brain damage: synergistic effects of ethanol, thiamine deficiency and alcoholic liver disease. Metab Brain Dis. 1995;10(1):1–8.Google Scholar
17 Freund, G, Ballinger, WE Jr. Alzheimer’s disease and alcoholism: possible interactions. Alcohol. 1992;9(3):233–40.Google Scholar
18 Mann, K, Widmann, U. The neurobiology of alcoholism. Neuropathology and CT/NMR findings. Fortschr Neurol Psychiatr. 1995;63(6):238–47.CrossRefGoogle ScholarPubMed
19 Goedde, HW, Agarwal, DP, Harada, S, et al. Population genetic studies on aldehyde dehydrogenase isozyme deficiency and alcohol sensitivity. Am J Hum Genet. 1983;35(4):769–72.Google Scholar
20 Stewart, MJ, Malek, K, Crabb, DW. Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J Investig Med. 1996;44(2):42–6.Google Scholar
21 Tan, EC, Lim, L, Leong, JY, et al. Alcohol and aldehyde dehydrogenase polymorphisms in Chinese and Indian populations. Subst Use Misuse. 2010;45(1-2):1–14.Google Scholar
22 Butterfield, DA, Bader Lange, ML, Sultana, R. Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer’s disease. Biochim Biophys Acta. 2010;1801(8):924–9.Google Scholar
23 Ohsawa, I, Nishimaki, K, Murakami, Y, Suzuki, Y, Ishikawa, M, Ohta, S. Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J Neurosci. 2008;28(24):6239–49.Google Scholar
24 Bai, J, Mei, Y. Overexpression of aldehyde dehydrogenase-2 attenuates neurotoxicity induced by 4-hydroxynonenal in cultured primary hippocampal neurons. 2010 Apr 2. [Epub ahead of print].Google Scholar
25 Olafsdottir, H, Raitasalo, K, Greenfield, TK, Allamani, A. Concern about family members’ drinking and cultural consistency: a Multi-Country GENACIS Study. Contemp Drug Probl. 2009;36 (1):1.Google Scholar
26 Perera, B, Fonseka, P, Ekanayake, R, Lelwala, E. Smoking in adults in Sri Lanka: prevalence and attitudes. Asia Pac J Public Health. 2005;17(1):40–5.CrossRefGoogle ScholarPubMed
27 Tyas, SL, Koval, JJ, Pederson, LL. Does an interaction between smoking and drinking influence the risk of Alzheimer’s disease? Results from three Canadian data sets. Stat Med. 2000;19(11-12):1685–96.Google Scholar
28 Greene, CS, Penrod, NM, Williams, SM, Moore, JH. Failure to replicate a genetic association may provide important clues about genetic architecture. PLoS One. 2009;4(6):e5639.Google Scholar
29 Chen, JH, Lin, KP, Chen, YC. Risk factors for dementia. J Formos Med Assoc. 2009;108(10):754–64.Google Scholar
30 Stern, Y, Gurland, B, Tatemichi, TK, Tang, MX, Wilder, D, Mayeux, R. Influence of education and occupation on the incidence of Alzheimer’s disease. JAMA. 1994;271(13):1004–10.Google Scholar
31 Wen, J, Ren, Y, Wang, L, et al. The reporting quality of meta-analyses improves: a random sampling study. J Clin Epidemiol. 2008;61 (8):770–5.Google Scholar