Hostname: page-component-5c6d5d7d68-ckgrl Total loading time: 0 Render date: 2024-09-01T01:24:18.106Z Has data issue: false hasContentIssue false
  • English
  • Français

Peripheral Neuropathy in Oxalosis. A Case Report with Electron Microscopic Observations

Published online by Cambridge University Press:  18 September 2015

Juan M. Bilbao ,
Henry Berry ,
Joseph Marotta  and
Roderick C. Ross
Juan M. Bilbao*
Affiliation:
Departments of Pathology and Neurology, St. Michaels Hospital, and the University of Toronto
Henry Berry
Affiliation:
Departments of Pathology and Neurology, St. Michaels Hospital, and the University of Toronto
Joseph Marotta
Affiliation:
Departments of Pathology and Neurology, St. Michaels Hospital, and the University of Toronto
Roderick C. Ross
Affiliation:
Departments of Pathology and Neurology, St. Michaels Hospital, and the University of Toronto
*
Department of Pathology, St. Michaels Hospital, 30 Bond Street, Toronto M5B IW8, Ontario, Canada
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A 61 year old man had chronic renal failure because of oxaluria and renal calculi. Two years before death, while on hemodialysis, he developed severe progressive peripheral neuropathy. At autopsy calcium oxalate crystals were found in the peripheral nerves and other tissues. Nerve lesions included segmental demyelination, axonal degeneration and crystalline deposits within the myelin sheath. Ultrastructurally there were foci of osmiophilic granular material within myelin lamellae and endoneurium, and pleomorphic lamellar bodies in the perinuclear Schwann cell cytoplasm.

It is probable that chronic hemodialysis favors the deposition of oxalate in the Schwann cells and the development of neuropathy in patients with primary hyperoxaluria and renal failure.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 3 , Issue 1 , February 1976 , pp. 63 - 67
Copyright
Copyright © Canadian Neurological Sciences Federation 1976

References

REFERENCES

Barbizet, J., Worms, R., Brion, S., Mikol, J., Descroix, R., et Galian, A. (1971). Observation anatomo-clinique d’une oxalose généralisée associée à une sclerose du cervelet. Révue Neurologique, 125, 409–423.Google Scholar
Boquist, L., LindqvlSt, B., Oestberg, Y. and Steen, L. (1973). Primary oxalosis. The American Journal of Medicine, 54, 673–681.CrossRefGoogle ScholarPubMed
Dinn, J.J. and Crane, D.L. (1970). Schwann cell dysfunction in uremia. Journal of Neurology Neurosurgery and Psychiatry, 33, 605–608.CrossRefGoogle Scholar
Dunn, H.G. (1955). Oxalosis. Report of a case with review of the literature. The American Journal of Diseases of Children, 90, 58–80.Google ScholarPubMed
Dyck, P.J., Johnson, W.J., Lambert, E.H. and O’brien, P.C. (1971). Segmental demyelination secondary to axonal degeneration in uremic neuropathy. Mayo Clinic Proceedings, 46, 400–436.Google ScholarPubMed
Dyck, P.J., Johnson, W.J., Lambert, E.H.Bushek, W. and Pollock, M. (1975) Detection and evaluation of uremic peripheral neuropathy in patients on hemodialysis. Kidney International 7, Supplement No. 2, 201–205.Google ScholarPubMed
Fonck-Cussac, Y., Aublet-Cuvelier, J.L., Fonck, J. et Delage, J. (1971). Etude ultrastructural du rein dans l’oxalose expérimentale par l’ethylene glycol. Annales d’anatomie Pathologique (Paris), 16, 153–158.Google ScholarPubMed
Hall, E.G., Scowen, E.F. and Watts, R.W.E. (1960) Clinical manifestations of primary hyperoxaluria. Archives of Disease in Childhood, 35, 108–112.CrossRefGoogle ScholarPubMed
Hockaday, T.D.R., Clayton, J.E., Frederick, E.W. and Smith, L.H. Jr. (1964). Primary hyperoxaluria. Medicine, 43, 315–345.CrossRefGoogle ScholarPubMed
Hughes, D.T. (1959). The clinical and pathological background of two cases of oxalosis. Journal of Clinical Pathology, 12, 498–509.CrossRefGoogle ScholarPubMed
Jebsen, R.H., Tenckhoff, H. and Honet, J.C. (1967). Natural history of uremic polyneuritis and effect of dialysis. New England Journal of Medicine, 277, 327–333.CrossRefGoogle Scholar
Johnson, F.B. (1972). Crystals in pathology specimens. In Pathology Annual, edited by Sommers, S.C. Vol. 7. Appleton-Century-Crofts, New York.Google Scholar
Katzuni, E. and Sanbank, U. (1959). Oxalosis. Archives of Disease in Childhood, 34, 60–62.CrossRefGoogle ScholarPubMed
Koten, J.W., Vangastel, C, Dorhout Mees, E.J., Holleman, L.W.J. and Schuiling, R.D. (1965). Two cases of primary oxalosis. Journal of Clinical Pathology, 18, 223–229.CrossRefGoogle ScholarPubMed
Mahoney, J.F., Storey, B.G., McCarthy, S.W. and Stewart, J.H. (1972). Treatment of oxaluric renal failure. New England Journal of Medicine, 287, 1252–1253.Google Scholar
Neustein, H.B., Stevenson, S.S. and Krainer, L. (1955). Oxalosis with renal calcinosis due to calcium oxalate. Journal of Pediatrics, 47, 624–633.CrossRefGoogle ScholarPubMed
Pons, C.A. and Custer, R.P. (1946). Ethylene glycol poisoning. A clinico-pathologic report of 18 cases. The American Journal of Medical Science, 211, 544–552.Google ScholarPubMed
Roscher, A.A. (1971). A new histochemical method for the demonstration of Ca oxalate in tissues following ethylene glycol poisoning. The American Journal of Clinical Pathology, 55, 99–104.CrossRefGoogle Scholar
Scowen, E.F., Stansfield, A.G. and Watts, R.W.E. (1959). Oxalosis and primary oxaluria. Journal of Pathology and Bacteriology, 77, 195–205.CrossRefGoogle Scholar
Tomonaga, M. and Sluga, E. (1970). Zur ultrastruktur der π granula: Acta Neuropathology (Berlin) 15, 56–69.Google Scholar
Tenckhoff, H.A., Boen, F.T., Jebsen, R.H. and Spiegler, J.H. (1965). Polyneuropathy in chronic renal insufficiency. Journal of American Medical Association, 192, 91–94.CrossRefGoogle ScholarPubMed
Walls, J., Morley, A. and Kerr, D.N.S. (1969). Primary hyperoxaluria in adult siblings. With some observations on the role of regular hemodialysis therapy. British Journal of Urology, 41, 546–553.CrossRefGoogle Scholar
Williams, H.E. and Smith, L.H. (1972). Primary hyperoxaluria. Stanbury, J.S. Editor. The metabolic basis of inherited disease. McGraw Hill Book Company, 196–219.Google Scholar
Ying Chou, L. and Donohue, W.L. (1952). Oxalosis: “inborn error of metabolism” with nephrolithiasis and nep-hrocalcinosis due to calcium oxalate as predominating features. Journal of Pediatrics, 10, 660–666.CrossRefGoogle Scholar
Zarembski, P.M., Rosen, S.M. and Hodgkinson, A. (1969). Dialysis in the treatment of primary hyperoxaluria. British Journal of Urology, 41, 530–533.CrossRefGoogle ScholarPubMed