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Photo-Dynamic Therapy: Cavitary Photo-Illumination of Malignant Cerebral Tumours Using a Laser Coupled Inflatable Balloon

Published online by Cambridge University Press:  18 September 2015

Paul J. Muller  and
Brian C. Wilson
Paul J. Muller
Affiliation:
Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, University of Toronto and the Department of Medical Physics, Ontario Cancer Treatment and Research Foundation, Hamilton, Ontario
Brian C. Wilson
Affiliation:
Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, University of Toronto and the Department of Medical Physics, Ontario Cancer Treatment and Research Foundation, Hamilton, Ontario
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Abstract:

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Interest in photodynamic therapy of malignant brain tumours has been growing in recent years as intra-operative laser applications become more available.

We have developed an inflatable balloon which can be coupled to an argon dye pump laser in order to deliver light to a brain tumour cavity created by the subtotal resection of tumour. Eight patients with primary malignant brain tumours have been treated with photodynamic therapy (PDT) using this device. The 8 patients tolerated the treatment well; morbidity attributable to the PDT was acceptably low.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 12 , Issue S4 , November 1985 , pp. 371 - 373
Copyright
Copyright © Canadian Neurological Sciences Federation 1985

References

REFERENCES

1.Dougherty, TJ, Weishaupt, KR, Boyle, DG. Photosensitizers. In: Devita, VT, Helman, S, Rosenberg, SA (eds). Cancer. Philadelphia: JP Lippincott, 1982.Google ScholarPubMed
2.Auler, H, Banzer, G. Untersuchungen uber die rolle der prophine bei geschwulstkranken menschen und tieren. Z Krebsforsch, 1924; 53: 65–69.CrossRefGoogle Scholar
3.Lipson, RL, Baldes, EJ, Olsen, AM. The use of a derivative of hematoporphyrin in tumor detection. J Nat Cancer Inst, 1961; 26: 1–11.Google Scholar
4.Laws, ER, Cortese, DA, Kinsey, JH, et al. Photoradiation therapy in the treatment of malignant brain tumors: A feasibility study. Neurosurgery 1981; 9: 672–678.CrossRefGoogle Scholar
5.Kohn, K, Kessel, D. On the mode of cytotoxic action of photoactivated porphyrins. Biochem Pharmacol, 1979; 28: 2465–2470.CrossRefGoogle Scholar
6.Weishaupt, KR, Gomer, CJ, Dougherty, TJ. Identification of singlet oxygen as the cytotoxic agent in photo-inactivation of a murine tumor. Cancer Res, 1976; 36: 2326–2329.Google Scholar
7.Wilson, BC, Jeesves, WP. Photodynamic therapy in cancer. In: Ben-Hur, E and Rosenthal, I (eds). Photomedicine. Cleveland: CRC Press Inc. (in press).Google Scholar
8.Dougherty, TJ, Lawrence, G, Kaufman, JH, et al. Photoradiation therapy in the treatment of recurrent breast carcinoma. J Nat Cancer Inst, 1979; 62: 231–237.Google ScholarPubMed
9.Dahlman, A, Wile, AG, Burns, RG, et al. Laser photoradiation therapy of cancer. Cancer Res, 1983; 43: 430–434.Google ScholarPubMed
10.Perria, C, Capuzzo, T, Cavagnaro, G, et al. First attempts at the photodynamic therapy of human gliomas. J Neurosurg Sci, 1980; 24: 119–129.Google ScholarPubMed
11.Laws, ER, Wharen, JR. RE: Comments. Neurosurgery 1984; 15: 808–809.Google Scholar
12.McCulloch, GAJ, Forbes, IJ, Lee See, K, et al. Phototherapy in malignant brain tumors. In: Doiron, DR, Gomer, CJ (eds). Porphyrin Localization and Treatment of Tumors. New York: A.R. Liss Inc., 1984: 709–718.Google Scholar
13.Wilson, BC, Muller, PJ, Yanche, JC. Instrumentation and light dosimetry for intraoperative photodynamic therapy (PDT) of malignant brain tumors. Physics in Med and Biol (in press).Google Scholar
14.Appuzzo, ML. Comments. Neurosurgery 1984; 15: 809–810.Google Scholar