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Primary Lymphoma of the Central Nervous System: Manitoba Experience and Literature Review

Published online by Cambridge University Press:  18 September 2015

Douglas E. Hobson ,
Brian A. Anderson ,
Ian Carr  and
Michael West
Douglas E. Hobson
Affiliation:
Department of Medicine, University of Manitoba, Winnipeg
Brian A. Anderson*
Affiliation:
Department of Medicine, University of Manitoba, Winnipeg
Ian Carr
Affiliation:
Department of Pathology, University of Manitoba, Winnipeg
Michael West
Affiliation:
Department of Surgery, University of Manitoba, Winnipeg
*
Department of Medicine, St.Boniface Hospital, 409 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
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Abstract:

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We describe eight cases of primary cerebral lymphoma seen in Manitoba from 1980 to 1985.

The clinical presentation is similar to other primary brain tumors. The diagnosis should be considered when single or multiple, often deep lesions, show dense enhancement on computerized tomographic (CT) scan, but are avascular at angiography. These tumors are histologically indistinguishable from non-Hodgkins lymphomas arising outside the CNS.

The prognosis is poor. However, radiotherapy with or without surgery may offer significant palliation. Although there is no consensus on the value of chemotherapy, corticosteroids alone or multiagent chemotherapy have shown promise in a few cases. For these reasons, histologic diagnosis should be sought in all cases and surgery, radiotherapy, and chemotherapy should be considered, as prolonged survival is possible.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue 1 , February 1986 , pp. 55 - 61
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

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