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Recurrent Spontaneous Seizure State Induced by Prefrontal Kindling in Senegalese Baboons, Papio Papio

Published online by Cambridge University Press:  18 September 2015

J.A. Wada ,
T. Osawa  and
T. Mizoguchi
J.A. Wada*
Affiliation:
Division of Neurological Sciences, Faculty of Medicine, University of British Columbia
T. Osawa
Affiliation:
Division of Neurological Sciences, Faculty of Medicine, University of British Columbia
T. Mizoguchi
Affiliation:
Division of Neurological Sciences, Faculty of Medicine, University of British Columbia
*
Division of Neurological Sciences, University of British Columbia, 2075 Westbrook Place, Vancouver, Canada V6T 1W5
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In our earlier study of amygdaloid kindling in Papio papio (Pp), the development of partial complex seizure and of focal motor seizure was correlated with bifrontal theta discharge and increasing Rolandic spike discharge respectively and the final stage was characterized by primary generalized convulsive seizure. Since the latter seizure pattern is known to originate from the frontal focus in man, the frontal cortex became suspect in the development of the final stage seizure pattern. Daily prefrontal stimulation showed that Pp can be kindled from this site, culminating in a recurrent spontaneous seizure state identical to that induced by amygdaloid kindling in this species. However, our observation did not support our original assumption regarding the genesis of primary generalized convulsive seizure. Prefrontal and amygdaloid kindling are significantly different with respect to morphology, distribution and propagation of afterdischarge and interictal spike discharge, and speed and pattern of clinical seizure development. Most intriguingly, inter-ictal behavioral aberration associated with depth EEG changes was observed only in the prefrontal animals and not in the amygdaloid animals.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 4 , November 1975 , pp. 477 - 492
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

References

REFERENCES

Ajmone Marsan, C. and Goldhammer, L. (1973). Clinical ictal pattern and electrographic data in cases of partial seizures of fronto-central-parietal origin. In Epilepsy: Its phenomenon in Man. (Ed. Brazier, M.A.B.) 236–258, University of California, Los Angeles Forms in Medical Sciences, Number 17, Los Angeles.Google Scholar
Bancaud, J., Talailach, J., Morel, P., Bresson, M., Bonis, A., Geier, E. and Buser, P. (1974). “Generalized” epileptic seizures elicited by electrical stimulation of the frontal lobe in man. Electroencephalography and Clinical Neurophysiology, 37, 269–274.CrossRefGoogle ScholarPubMed
Goddard, G.V., McIntyre, D.C. and Leech, C.K. (1969). A permanent change in brain functions resulting from daily electrical stimulation. Experimental Neurology, 25, 295–330.CrossRefGoogle ScholarPubMed
Goldring, S. (1972). The role of prefrontal cortex in grand mal convulsion. Archives of Neurology, 26, 109–119.CrossRefGoogle ScholarPubMed
Jasper, H., Ajmone Marsan, C and Stoll, J. (1952). Cortico-fugal projections to the brain stem. American Medical Association Archives of Neurology and Psychiatry, 67, 155–166.CrossRefGoogle Scholar
Kaada, B.R and Johannessen, N.B. (1960). Generalized electrocortical activation by cortical stimulation in the cat. Electroencephalography and Clinical Neurophysiology, 12, 567–573.CrossRefGoogle ScholarPubMed
Kretteck, J.E. and Price, J.L. (1974). A direct input from the amygdala to the thalamus and the cerebral cortex. Brain Research 67: 169–174.CrossRefGoogle Scholar
Nauta, W.J.H. (1962). Neural associations of the amygdaloid complex in the monkey. Brain 85, 505–520.CrossRefGoogle ScholarPubMed
Nauta, W.J.H. (1964). Some efferent connections of the prefrontal cortex in the monkey. In: The frontal granular cortex and behavior. (Eds. Warren/Akert) 397–409, McGraw-Hill, New York.Google Scholar
Penfield, W. and Jasper, H. (1954). Epilepsy and the functional anatomy of the human brain. p. 150, Little, Brown and Company, Boston.Google Scholar
Rasmussen, T. (1975). Surgery of frontal lobe epilepsy. In: Advances in Neurology, Vol. 8: Neurosurgical management of the epilepsies. (Eds. Purpura, D.P.Penry, J.K. and Walter, R.D.), p. 197–205, Raven Press, New York.Google Scholar
Stratford, J. (1954). Cortico-thalamic connections from gyrus proreus and first and second sensory areas of the cat. Journal of Comparative Neurology, 100, 1–14.CrossRefGoogle Scholar
Teramoto, H. (1974). An experimental study on psychomotor epilepsy — the functional relationship and differentiation between mediodorsal thalamic nucleus, anteroventral thalamic nucleus and the cingulate gyrus. (Japanese). Psychiatria et Neurologia Japonica. 76/6, 319–320.Google Scholar
Wada, J.A. (1961). Permanent ventricular canula, simplified electrode system and behavioral observation box for the macaca monkey. Electroencephalography and Clinical Neurophysiology, 13, 298–301.CrossRefGoogle Scholar
Wada, J.A., Terao, A. and Booker, H.E. (1972). Longitudinal correlative analysis of epileptic baboon, Papio papio. Neurology, 22, 1272–1285.CrossRefGoogle ScholarPubMed
Wada, J.A., Sato, M. and McCaughran, , 7 (In Press). Cortical electrographic correlates of amygdaloid seizure development in rats, cats and baboons. Folia psychiatrica et Neurologica Japonica.Google Scholar
Wada, J.A. and Osawa, T. (In press). Generalized convulsive seizure state induced by daily electrical amygdaloid stimulation in Senegalese baboon, Papio papio. Neurology.Google Scholar
Wada, J.A., Mizoguchi, T. and Osawa, T. (Unpublished data). Progressive seizure development by daily electrical stimulation of amygdala in rhesus monkeys.Google Scholar