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Sodium Valproate in the Treatment of Cerebellar Disorders
Published online by Cambridge University Press: 18 September 2015
Summary:
Because of the high concentrations of ɣ-aminobutyric acid (GABA) in the cerebellar cortex and nuclei, an attempt was made to enhance GABAergic transmission in patients with cerebellar disease. Maximum tolerated doses of sodium valproate, a drug which inhibits the degradation of GABA, failed to influence cerebellar deficits in a double blind crossover study on six patients.
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- Copyright © Canadian Neurological Sciences Federation 1979
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