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Split-Brain Rat: Transfer and Interference of Kindled Amygdala Convulsions

Published online by Cambridge University Press:  18 September 2015

Dan C. McIntyre
Dan C. McIntyre*
Affiliation:
Department of Psychology, Carleton University, Ottawa, Canada
*
Department of Psychology, Carleton University, Ottawa, Canada
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Summary:

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Rats were subjected to varying degrees of commissurotomy, followed by implantation of a bipolar electrode into each amygdala. After the kindling of six convulsions at one electrode (primary site), the procedure was applied to the contralateral amygdala (secondary site). Convulsions were observed to develop more rapidly, independent of the degree or kind of transection. After 6 secondary site convulsions, the primary site was re-tested and convulsion-triggering was blocked, except in animals with transection of the rostral portion of the corpus callosum (CC).

Collectively, the data indicate: (i) amygdala kindling develops a lasting trace which operates through the midbrain or brainstem; (ii) kindling from a second site utilizes this trace; (iii) a series of 6 convulsions produces negative after-effect which manifests itself at the convulsion level via the anterior CC; (iv) the anterior CC is important in determining the laterality of the forelimb clonus; and (v) the inter-amygdala propagation of after-discharge is blocked by the combined sectioning of the anterior CC and the anterior commissure.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 4 , November 1975 , pp. 429 - 437
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

References

Burnham, W.M. (1971). Epileptogenic modification of the rat forebrain by direct and trans-synaptic stimulation. Doctoral Dissertation, McGill University.Google Scholar
Degroot, J. (1963). The Rat Forebrain in Stereotaxic Coordinates. North-Holland, Amsterdam.Google Scholar
Frost, L.L.Baldwin, M. and Wodd, C.D. (1958). Investigation of the primate amygdala: movements of the face and jaws. Neurology, 8, 543–546.CrossRefGoogle ScholarPubMed
Goddard, G.V.McIntyre, D.C. and Leech, C.K. (1969). A permanent change in brain function resulting from daily electrical stimulation. Experimental Neurology, 25, 295–330.CrossRefGoogle ScholarPubMed
McIntyre, D.C. and Goddard, G.V. (1973). Transfer, interference and spontaneous recovery of convulsions kindled from the rat amygdala. Electroencephalography and Clinical Neurophysiology, 35, 533–543.CrossRefGoogle ScholarPubMed
Mutani, R.Berganini, L.Fariello, R. and Quattrocolo, G.(1972). An experimental investigation on the mechanisms of interaction of asymmetrical acute epileptic foci. Epilepsia, 13, 597–608.CrossRefGoogle ScholarPubMed
Pinel, J.P.Phillips, A.H. and Macneill, B. (1973). Blockage of highlystable “kindled” seizures in rats by antecedent footshock. Epilepsia, 14, 29–37.CrossRefGoogle ScholarPubMed
Problete, R.Ruben, R. and Walker, A.E. (1959). Propagation of after-discharge between temporal lobes. Journal of Neurophysiology, 22, 538–553.CrossRefGoogle Scholar
Racine, R.J. (1972). Modification of seizure activity by electrical stimulation: 11. Motor seizure. Electroencephalography and Cliniical Neurophysiology. 32, 281–294.CrossRefGoogle Scholar
Racine, R.J.Okujava, V. and Chipashvili, S. (1972). Modification of seizure activity by electrical stimulation: 111 Mechanisms. Electroencephalography and Clinical Neurophysiology, 32, 295–299.CrossRefGoogle Scholar
Tanaka, A. (1972). Progressive changes of behavioral and electrographic responses to daily amygdaloid stimulation in rabbits. Fukuoka Acta Medica, 63, 152–164.Google Scholar
Wada, J. and Sato, M. (1973). Generalized convulsive seizure state induced by daily electrical stimulation of the amygdala in split-brain cats. Paper delivered to the American Electroencephalography Association, Boston.Google Scholar
Wada, J.A. and Sato, M. (1974). Generalized convulsive seizures induced by daily electrical stimulation of the amygdala in cats. Neurology, 24, 565–574.CrossRefGoogle ScholarPubMed
Wada, J.A.Sato, M. and Corcoran, M.E. (1974). Persistent seizure susceptibility and recurrent spontaneous seizures in kindled cats. Epilepsia, 15, 465–478.CrossRefGoogle ScholarPubMed