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Two Types of Spheroid Bodies in the Nigral Neurons in Parkinson's Disease

Published online by Cambridge University Press:  18 September 2015

Tatsuo Yamada ,
Haruhiko Akiyama  and
Patrick L. McGeer
Tatsuo Yamada*
Affiliation:
Kinsmen Laboratory of Neurological Research, Department of Psychiatry and The Neurodegenerative Diseases Centre, University of British Columbia, Vancouver
Haruhiko Akiyama
Affiliation:
Kinsmen Laboratory of Neurological Research, Department of Psychiatry and The Neurodegenerative Diseases Centre, University of British Columbia, Vancouver
Patrick L. McGeer
Affiliation:
Kinsmen Laboratory of Neurological Research, Department of Psychiatry and The Neurodegenerative Diseases Centre, University of British Columbia, Vancouver
*
2255 Wesbrook Mall, University of B.C., Vancouver, British Columbia, Canada V6T 1W5
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Abstract:

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Dendritic spheroid bodies (SBs) and Lewy bodies (LBs) were identified in comparable numbers in the substantia nigra pars compacta (SBC) of nine parkinsonian cases and one case of striatonigral degeneration but were not found irt cases of Huntington's disease or neurologically normal controls. The immunohistochemical profile of the SBs in dystrophic dendrites of nigrostriatal dopaminergic neurons was remarkably similar to that of the LBs found within dendrites or free of the SNC neuropil. Both types of inclusions stained positively with antibodies to tyrosine hydroxylase, ubiquitin and microtubule-associated protein-2 (MAP2), and negatively for Tau-2, although they had different ultrastructural appearances. A few intracellular LBs were stained by antibodies to neurofilament proteins (NFs) 68, 160, and 200 kD, but dendritic SBs and extracellular LBs were not so stained. These data indicate that dendritic SBs and extracellular LBs may have a common molecular pathogenetic origin in Parkinson's disease. On the other hand, the SBs seen in the pars reticulata (SNR) and in the distal nigrostriatal axons even in control cases were generally stained by antibodies to NFs and ubiquitin but not to MAP2. This latter staining pattern in similar to that shown by SBs in the anterior horn in ALS and in the cerebellum of neurologically normal brains and is believed typical of axonal as opposed to dendritic SBs.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue 3 , August 1991 , pp. 287 - 294
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

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