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Vitamin E Deficiency and Seizures in Animals and Man

Published online by Cambridge University Press:  18 September 2015

A.O. Ogunmekan
A.O. Ogunmekan*
Affiliation:
Department of Pediatrics (Division of Neurology), The Hospital for Sick Children, Toronto, Ontario
*
Department of Pediatrics, Lagos University Teaching Hospital, P.M.B. 12003, Lagos, Nigeria.
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Summary

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Study of 100 children with grand mal convulsive disorders and 100 medically healthy children of matching age showed significantly lower plasma levels of vitamin E in the former (means 632.2 ± 17.3 and 822.5 ± 2\.Zßg/dl respectively; p < 0.001). This finding accords with the ability to prevent seizures in rodents by giving a-tocopherol before exposing them to a convulsion-inducing environment.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 6 , Issue 1 , February 1979 , pp. 43 - 45
Copyright
Copyright © Canadian Neurological Sciences Federation 1979

References

Behnke, A. R. (1940). High atmosphere pressures; physiological effects increased and decreased pressure; application of these findings to clinical medicine. Ann Intern Med, 13, 2217–2228.Google Scholar
B1Eri, J. G., Poukka, R. K. H., and Príval, E. L. (1970). Determination of α-tocopherol in erythrocytes by gas-liquid chromatography. J Lipid Res, 11, 118–130.Google Scholar
Jerrett, S. A., Jefferson, D., and Mengel, C. E. (1973). Seizures H2O2 formation and lipid peroxides in brain during exposure to oxygen under high pressure. Aerosp Med, 44, 40–44.Google ScholarPubMed
Ogunmekan, A. O. (1977). Is There A Role for Vitamin E Therapy in Epilepsy in Man? M.D. Thesis; University of Newcastle-upon-Tyne, England.Google Scholar