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Influence of Age and of Dietary Restriction on the Mouse Aorta1

Published online by Cambridge University Press:  29 November 2010

Hildegard E. Enesco ,
Marie Laskey  and
Carole Verdone-Smith
Hildegard E. Enesco
Affiliation:
Sir George Williams Campus Concordia University
Marie Laskey
Affiliation:
Sir George Williams Campus Concordia University
Carole Verdone-Smith
Affiliation:
Sir George Williams Campus Concordia University
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Abstract

This study was designed to examine morphological changes in cross sections of the thoracic aorta of male Swiss albino mice during the course of aging. Histometric measurements made on the aortas of mice at 1, 3, 10 and 17.5 months of age showed that the tunica media, which consists of elastin lamellae and smooth muscle layers, thickens significantly with advancing age. To evaluate the effects of dietary restriction on the aorta, the aortas of 20 month old mice on a 4% protein diet (restricted) were compared with those on a 26% protein diet (control). The aortas of the 26% protein fed mice were significantly thicker and the number of elastin lamellae was significantly greater than those of the 4% protein fed mice. The control mice showed a greater degree of age related changes in the aorta than did mice on the protein restricted diet.

Résumé

Dans cette étude, nous examinons les modifications morphologiques sur les sections transverales de l'aorte thoracique de souris mâles “Swiss albino” pendant le processus de vieillissement. Des mesures histométriques de l'aorte de souris âgées de 1, 3, 10 et 17.5 mois démontrèrent que la media, constituée de lamelles élastiques et de muscles lisses, s'épaissit avec l'âge.

Afin d'évaluer les effets sur l'aorte d'une diète limitée en protéine, les aortes de souris âgées de 20 mois et nourries d'une diète de 4% en protéine furent comparées à celles de souris alimentées d'une diète de 26% en protéine (contrôle). L'épaisseur et le nombre de lamelles élastiques des aortes de souris contrôles s'avérèrent significativement plus grands que chez les souris alimentées d'une diète à 4% en protéine. Les aortes de souris nourries d'une diète de 26% en protéine démontrèrent un plus grand degré d'altérations morphologiques relatives au viellissement que les souris alimentées d'une diète limitée en protéine (4%).

Type
Articles
Information
Canadian Journal on Aging / La Revue canadienne du vieillissement , Volume 2 , Issue 4 , December 1983 , pp. 169 - 176
Copyright
Copyright © Canadian Association on Gerontology 1983

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References

REFERENCES

Abramson, OI, Turman, GA: Ageing changes in blood vessels. In: Bourne, GH, ed. Structural aspects of ageing. New York: Hafner, 1961: 49–59.Google Scholar
Andrew, W, Hickman, CP: Histology of the vertebrates: a comparative text. Saint Louis: Mosby, 1974.Google Scholar
Barrows, CH, Kokkonen, G: Diet and life extension in animal model systems. Age 1978; 1: 130–142.Google Scholar
Bruning, JL, Kintz, BL: Computational handbook of statistics. 2nd ed.Glenview, IL: Scott, Fores-man, 1977.Google Scholar
Cliff, WJ: The aortic tunica media in aging rats. Exp Mol Pathol 1972; 16: 382–402.Google Scholar
Everitt, AV: Cardio-vascular aging and the pituitary. In: Everitt, AV, Burgess, JA, eds. Hypothalamus, pituitary and aging. Springfield: Charles C. Thomas, 1976: 262–281.Google Scholar
Fulmer, HM, Lillie, RD: A selective stain for elastic tissue. Stain Technol 1956; 31: 27–30.Google Scholar
Getty, R: Histomorphological studies in the dog and hog as related to ageing. In: Lindop, PJ, Sacher, GA, eds. Radiation and ageing. London: Taylor & Francis, 1966: 245–276.Google Scholar
Goyal, VK: Changes with age in the aorta of man and mouse. Exper Gerontol 1982; 17: 127–132.Google Scholar
Guay, M, Lamy, F: L'elastine, une proteine fibreuse inpliquée dans plusieurs processus pathologiques. Union Med Can 1980; 109: 1280–1285.Google Scholar
Hall, DA: The ageing of connective tissue. New York: Academic Press, 1976.Google Scholar
Ito, H, Okamoto, K: On elastin in aorta of SHRSP. Jpn Heart J 1977; 18: 592–593.Google Scholar
Ito, H, Yamamoto, K and Okamoto, K: On elastin in aorta of SHRSP (2). Jpn Heart J, 1978; 19: 568–569.CrossRefGoogle ScholarPubMed
Leto, S, Kokkonen, GC, Barrows, CH: Dietary protein, lifespan, and physiological variables in female mice. J Gerontol 1976; 31: 149–154.Google Scholar
McCay, CM, Maynard, LA, Sperling, G, Barnes, LL: Retarded growth, lifespan, ultimate body size and age changes in the albino rat after feeding diets restricted in calories. J Nutr 1939; 18: 1–13.CrossRefGoogle Scholar
Putt, FA: Manual of histopathological staining methods. New York: Wiley, 1972.Google Scholar
Ross, MH: Protein, calories and life expectancy. Fed Proc 1959; 18: 1190–1207.Google ScholarPubMed
Smith, C, Seiter, MM, Wang, HP: Aging changes in the tunica media of the aorta. Anat Record, 1951; 109: 13–39.CrossRefGoogle ScholarPubMed
Toda, T, Tsuda, N, Leszezynski, DE, Kummerow, FA: Morphological analysis of the aging process in human arteries and aorta. Acta Anat (Basel) 1980; 106: 34–44.Google Scholar
Wolinsky, H: Long term effects of hypertension on the rat aortic wall and their relation to concurrent aging changes. Circ Res 1972; 30: 301–309.Google Scholar
Wolinsky, H, Glagov, S: Structural basis for the static mechanical properties of the aortic media. Circ Res 1964; 14: 400–413.Google Scholar
Wolinsky, H, Glagov, S: A lamellar unit of aortic medial structure and function mammals. Circ Res 1967; 20: 99–111.Google Scholar