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Liver Polyploidy in Alzheimer's Disease

Published online by Cambridge University Press:  29 November 2010

M. Fisman ,
M.I. Laskey  and
H.E. Enesco
M. Fisman
Affiliation:
London Psychiatric Hospital
M.I. Laskey
Affiliation:
Concordia University.
H.E. Enesco
Affiliation:
Concordia University.
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Abstract

The amount of liver polyploidy in a group of patients with Alzheimer's disease (AD) was compared with that of an age-matched control group. There was great variability in the percentage of cells in each ploidy class from one individual to the next in both control and AD subjects. AD patients had a lower percentage of 2N cells, and a higher percentage of 4N cells than the controls. There was no difference in the percentage of 8N or 16N cells in AD, indicating that there was no shift to higher ploidy classes in AD. The most stringent statistical analysis failed to reveal statistically significant differences between the AD and control groups.

Résumé

Un nombre de noyaux hépatiques polyploides ont été étudiés chez des personnes humaines agées témoins et chez des malades affligés de la maladie d'Alzheimer (MA). On a trouvé une grande variabilité du degré de poly ploidie chez les individus de chaques groupes. Chez les MA, le pourcentage de noyaux 2N est plus bas tandis que celui des 4N est plus élevé. Par contre, on n'a pas décelé de différence entre les groupes pour la fréquence des noyaux 8N et 16N suggérant qu'il n'y a pas de tendance vers une élévation de polyploidie chez les MA. Une analyse statistique des plus rigoureuse ne démontre pas de différence significative dans la distribution de types de noyaux chez les deux groupes.

Keywords

liver polyploidyAlzheimer's Disease
Type
Articles
Information
Canadian Journal on Aging / La Revue canadienne du vieillissement , Volume 6 , Issue 4 , Winter/Hiver 1987 , pp. 264 - 270
Copyright
Copyright © Canadian Association on Gerontology 1987

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References

REFERENCES

1.Brasch, K. (1980). Endopolyploidy in vertebrate liver: Evolutionary perspective. Cell Biology International, 4, 217–226.CrossRefGoogle ScholarPubMed
2.Brier, S.S. (1980). Analyses of contingency tables under cluster sampling. Biometrika, 67, 591–596.CrossRefGoogle Scholar
3.Buckton, K.E., Whalley, L.J., Lee, M. and Christie, J.E. (1983). Chromosome changes in Alzheimer's presenile dementia. Journal of Medical Genetics, 20, 46–51.CrossRefGoogle ScholarPubMed
4.Carriere, R. (1969). The growth of liver parenchymal nuclei and its endocrine regulation. International Review of Cytology, 25, 201–277.CrossRefGoogle ScholarPubMed
5.Enesco, H.E., Laskey, M. and Fisman, M. (1987). Changes in polyploidy during aging in human liver. Canadian Journal on Aging, 5, 249–255.CrossRefGoogle Scholar
6.Enesco, H.E. and Samborsky, J. (1983). Liver polyploidy: Influence of age and the dietary restriction. Experimental Gerontology, 18, 79–87.CrossRefGoogle ScholarPubMed
7.Gahan, P.B. and Middleton, J. (1984). Euploidization of human hepatocytes from donors of different ages and both sexes compared with those of cases of Werner's Syndrome and Progeria. Experimental Gerontology, 19, 355–358.CrossRefGoogle ScholarPubMed
8.Helwig-Larsen, H. (1952). Nuclear class series. Acta Pathologica Scandia. (Köbenh) suppl., 92.Google Scholar
9.Nordensson, I., Adolfsson, R., Beckman, F., Bucht, G. and Winbald, B. (1980). Chromosomal abnormality in dementia of Alzheimer type. Lancet, I, 481–482.CrossRefGoogle Scholar
10.Nordensson, I., Beekman, G., Adolfsson, R., Bucht, G. and Winbald, B. (1983). Cytogenetic changes in patients with senile dementia. Age and Ageing, 12, 285–295.CrossRefGoogle ScholarPubMed
11.Pavai, I. and Enesco, H.E. (in preparation).Google Scholar
12.Shima, A. and Sugarhara, T. (1976). Age-dependent ploidy class changes in mouse hepoyatocyte nuclei as revealed by Feulgen-DNA cytophotometry.CrossRefGoogle Scholar
13.Sokal, R.R. and Rohlf, F.J. (1981). Biometry (2nd Edition), W.H. Freeman and Company, San Francisco.Google Scholar
14.Stahelin, H.B., Hofer, H.O., Vogel, M., Held, C. and Seiler, W.O. (1983). Energy and protein consumption in patients with senile dementia. Gerontology, 29, 145–148.CrossRefGoogle ScholarPubMed
15.Swartz, F.S. (1956). The development in the human liver of multiple DNA classes and their relationships to the age of the individual. Chromosoma, 8, 53–72.CrossRefGoogle Scholar
16.Tagliavini, F. and Pilieri, G. (1983). Radiosensitivity in Alzheimer's Disease and Parkinson's Disease. Lancet, I, 468–470.Google Scholar
17.Uryvaeva, I.V. (1981). Biological significance of liver cell polyploidy: An hypothesis. Journal of Theoretical Biology, 89, 557–571.CrossRefGoogle ScholarPubMed
18.Ward, B.E., Cook, R.H., Robinson, A. and Austin, J.H. (1979). Increased aneuploidy in Alzheimer's Disease. American Journal of Human Genetics, 3, 137–144.Google Scholar