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2D-Speckle tracking echocardiography contributes to early identification of impaired left ventricular myocardial function in children with chronic kidney disease

Published online by Cambridge University Press:  28 August 2018

Hasan Demetgul ,
Dilek Giray ,
Ali Delibas  and
Olgu Hallioglu
Hasan Demetgul
Affiliation:
Department of Pediatric Cardiology, Hatay Woman’s and Children’s Hospital, Hatay, Turkey
Dilek Giray*
Affiliation:
Department of Pediatric Cardiology, Tokat State Hospital, Tokat, Turkey
Ali Delibas
Affiliation:
Department of Pediatric Nephrology, Mersin University, Mersin, Turkey
Olgu Hallioglu
Affiliation:
Department of Pediatric Cardiology, Mersin University, Mersin, Turkey
*
Author for correspondence: Department of Pediatric Cardiology, Dilek Giray, Tokat State Hospital, Tokat 60230, Turkey. Tel: +90 324 241-0000; Fax: +90 324 241 0000; E-mail: ddilekkarabulut@hotmail.com
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Abstract

Introduction

The aim of this study is to determine early changes in cardiac function of children with chronic kidney disease by using 2D-speckle tracking echocardiography.

Method

The study included 38 children – 16 girls and 22 boys – diagnosed as having chronic kidney disease in the nephrology department with a glomerular filtration rate of <90 ml/minute/1.73 m2 for at least 3 months. A total of 37 – 15 girls and 22 boys – age- and sex-matched healthy children were included as the control group. 2D-Speckle tracking echocardiography was performed in all subjects.

Results

The mean age was 13.45±2.8 years in patients and 12.89±3.07 years in controls. Systolic and diastolic blood pressures and left ventricular mass index were significantly higher in patients (p<0.05). The values of mitral e, mitral a, mitral e/a ratio, and mitral deceleration time were not different between the groups. Tricuspid annular plane systolic excursion values were lower in patients (p<0.01). Global strain values in apical long-axis 3-chamber and 2-chamber views were significantly lower in patients (p<0.05). Longitudinal, radial, and circumferential peak systolic strain values were lower in patients, but the difference was statistically significant in all segments of longitudinal view and basal segment of circumferential view (p<0.05). Radial and circumferential systolic strain rates were significantly lower in patients in all three segments (p<0.05). Moreover, early diastolic strain rate was significantly lower in longitudinal and radial apical segments and in all segments of circumferential measurements in patients. Besides, strain rate e/a ratio was significantly lower in all longitudinal segments of patients (p=0.01).

Conclusion

The study concluded that 2D-speckle tracking echocardiography method can determine cardiac involvement earlier than conventional echocardiography in children with chronic kidney disease having preserved ejection fraction.

Keywords

2D-Speckle tracking echocardiographycardiac dysfunctionchronic kidney disease
Type
Original Article
Information
Cardiology in the Young , Volume 28 , Issue 12 , December 2018 , pp. 1404 - 1409
Copyright
© Cambridge University Press 2018 

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